Growth kinetics and power laws indicate distinct mechanisms of cell-cell interactions in the aggregation process.
Journal
Biophysical journal
ISSN: 1542-0086
Titre abrégé: Biophys J
Pays: United States
ID NLM: 0370626
Informations de publication
Date de publication:
01 02 2022
01 02 2022
Historique:
received:
13
07
2021
revised:
20
11
2021
accepted:
22
12
2021
pubmed:
31
12
2021
medline:
15
4
2022
entrez:
30
12
2021
Statut:
ppublish
Résumé
Cellular aggregation is a complex process orchestrated by various kinds of interactions depending on the environment. Different interactions give rise to different pathways of cellular rearrangement and the development of specialized tissues. To distinguish the underlying mechanisms, in this theoretical work, we investigate the spontaneous emergence of tissue patterns from an ensemble of single cells on a substrate following three leading pathways of cell-cell interactions, namely, direct cell adhesion contacts, matrix-mediated mechanical interaction, and chemical signaling. Our analysis shows that the growth kinetics of the aggregation process are distinctly different for each pathway and bear the signature of the specific cell-cell interactions. Interestingly, we find that the average domain size and the mass of the clusters exhibit a power law growth in time under certain interaction mechanisms hitherto unexplored. Further, as observed in experiments, the cluster size distribution can be characterized by stretched exponential functions showing distinct cellular organization processes.
Identifiants
pubmed: 34968426
pii: S0006-3495(21)03954-0
doi: 10.1016/j.bpj.2021.12.030
pmc: PMC8822615
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
481-490Informations de copyright
Copyright © 2021 Biophysical Society. Published by Elsevier Inc. All rights reserved.
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