Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads.

Australia Diterpenes / chemistry Hypoglycemic Agents / chemistry Plant Extracts / chemistry Plant Leaves / chemistry Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism Scrophulariaceae / chemistry
Eremophila glabra Flavonoids High-resolution inhibition profiling Protein-tyrosine phosphatase 1B Scrophulariaceae Serrulatane diterpenoids α-Glucosidase

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Apr 2022
Historique:
received: 25 10 2021
revised: 21 12 2021
accepted: 24 12 2021
pubmed: 2 1 2022
medline: 23 2 2022
entrez: 1 1 2022
Statut: ppublish

Résumé

Eremophila (Scrophulariaceae) is a genus of Australian desert plants, which have been used by Australian Aboriginal people for various medicinal purposes. Crude extracts of the leaf resin of Eremophila glabra (R.Br.) Ostenf. showed α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC

Identifiants

DOI: 10.1016/j.phytochem.2021.113072 PMID: 34973506
pubmed: 34973506
pii: S0031-9422(21)00421-0
doi: 10.1016/j.phytochem.2021.113072
pii:
doi:

Substances chimiques

Diterpenes 0
Hypoglycemic Agents 0
Plant Extracts 0
Protein Tyrosine Phosphatase, Non-Receptor Type 1 EC 3.1.3.48

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113072

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Malene J Petersen (MJ)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, Denmark.

Chao Liang (C)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, Denmark.

Louise Kjaerulff (L)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, Denmark.

Chi Ndi (C)

Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Sciences, University of South Australia, Frome Road, Adelaide, 5000, Australia.

Susan Semple (S)

Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Sciences, University of South Australia, Frome Road, Adelaide, 5000, Australia.

Bevan Buirchell (B)

Wise Owl Consulting, Como, Western Australia, 6152, Australia.

Sonia Coriani (S)

Department of Chemistry, Technical University of Denmark, Kemitorvet Building 207, DK-2800, Kongens Lyngby, Denmark.

Birger Lindberg Møller (BL)

Plant Biochemistry Laboratory, Department of Plant and Environment Sciences, University of Copenhagen, Thorvaldsensvej 40, DK-1871, Frederiksberg C, Denmark.

Dan Staerk (D)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, Denmark. Electronic address: ds@sund.ku.dk.

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Classifications MeSH

questionsmedicales.fr › Régions géographiques › Océanie › Australasie › Australie › Serrulatane diterpenoids from the leaves of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Serrulatane diterpenoids from the leaves of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Serrulatane diterpenoids from the leaves of...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Serrulatane diterpenoids from the leaves of...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Feuilles de plante › Serrulatane diterpenoids from the leaves of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein Tyrosine Phosphatases › Protein Tyrosine Phosphatases, Non-Receptor › Protein Tyrosine Phosphatase, Non-Receptor Type 1 › Serrulatane diterpenoids from the leaves of...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lamiales › Scrophulariaceae › Serrulatane diterpenoids from the leaves of...