Reduced Numbers of Corticotropin-Releasing Hormone Neurons in Narcolepsy Type 1.
Aged
Aged, 80 and over
Cell Count
Corticotropin-Releasing Hormone
/ metabolism
Female
Humans
Hypothalamus
/ diagnostic imaging
Immunohistochemistry
Locus Coeruleus
/ cytology
Male
Median Eminence
/ cytology
Middle Aged
Narcolepsy
/ diagnostic imaging
Neurons
/ pathology
Paraventricular Hypothalamic Nucleus
/ cytology
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
31
12
2021
received:
20
07
2021
accepted:
31
12
2021
pubmed:
5
1
2022
medline:
11
2
2022
entrez:
4
1
2022
Statut:
ppublish
Résumé
Narcolepsy type 1 (NT1) is a chronic sleep disorder correlated with loss of hypocretin(orexin). In NT1 post-mortem brains, we observed 88% reduction in corticotropin-releasing hormone (CRH)-positive neurons in the paraventricular nucleus (PVN) and significantly less CRH-positive fibers in the median eminence, whereas CRH-neurons in the locus coeruleus and thalamus, and other PVN neuronal populations were spared: that is, vasopressin, oxytocin, tyrosine hydroxylase, and thyrotropin releasing hormone-expressing neurons. Other hypothalamic cell groups, that is, the suprachiasmatic, ventrolateral preoptic, infundibular, and supraoptic nuclei and nucleus basalis of Meynert, were unaffected. The surprising selective decrease in CRH-neurons provide novel targets for diagnostics and therapeutic interventions. ANN NEUROL 2022;91:282-288.
Identifiants
pubmed: 34981555
doi: 10.1002/ana.26300
pmc: PMC9306683
doi:
Substances chimiques
Corticotropin-Releasing Hormone
9015-71-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
282-288Subventions
Organisme : H2020 Marie Sklodowska-Curie Actions
ID : 707404
Organisme : Klaus-Grawe Foundation
Informations de copyright
© 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
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