A Novel Layer 4 Corticofugal Cell Type/Projection Involved in Thalamo-Cortico-Striatal Sensory Processing.
GABAergic
auditory cortex
corticofugal
glutamatergic
layer 4
parvalbumin-expressing
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
23 02 2022
23 02 2022
Historique:
received:
26
08
2021
revised:
11
10
2021
accepted:
14
12
2021
pubmed:
6
1
2022
medline:
22
4
2022
entrez:
5
1
2022
Statut:
ppublish
Résumé
In sensory cortices, the information flow has been thought to be processed vertically across cortical layers, with layer 4 being the major thalamo-recipient which relays thalamic signals to layer 2/3, which in turn transmits thalamic information to layer 5 and 6 to then leave the cortex to reach subcortical and cortical long-range structures. Although several exceptions to this model have been described, neurons in layer 4 are still considered to establish only local (i.e., interlaminar and short-range) connections. Here, taking advantage of anatomic, electrophysiological, and optogenetic techniques, we describe, for the first time, a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) of the mouse auditory cortex that receive direct thalamic inputs. The CS-L4 neurons are embedded in a feedforward inhibitory circuit involving local parvalbumin neurons and establish connections in the posterior striatum in yet another feedforward inhibitory thalamo→cortico(L4)→striatal circuit which potentially contributes in controlling control the output of striatal spiny projection neurons.
Identifiants
pubmed: 34983816
pii: JNEUROSCI.1738-21.2021
doi: 10.1523/JNEUROSCI.1738-21.2021
pmc: PMC8883864
doi:
Substances chimiques
Parvalbumins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1383-1405Subventions
Organisme : NIMH NIH HHS
ID : R01 MH123260
Pays : United States
Organisme : NIGMS NIH HHS
ID : SC1 GM122645
Pays : United States
Informations de copyright
Copyright © 2022 the authors.
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