Emergence of methicillin resistance predates the clinical use of antibiotics.

Animals Anti-Bacterial Agents / history Arthrodermataceae / genetics Denmark Europe Evolution, Molecular Geographic Mapping Hedgehogs / metabolism History, 20th Century Humans Methicillin Resistance / genetics Methicillin-Resistant Staphylococcus aureus / genetics New Zealand One Health Penicillins / biosynthesis Phylogeny Selection, Genetic / genetics beta-Lactams / metabolism

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
02 2022
Historique:
received: 12 05 2021
accepted: 18 11 2021
pubmed: 7 1 2022
medline: 11 3 2022
entrez: 6 1 2022
Statut: ppublish

Résumé

The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of antibiotics

Identifiants

DOI: 10.1038/s41586-021-04265-w PMID: 34987223 PMC: PMC8810379
pubmed: 34987223
doi: 10.1038/s41586-021-04265-w
pii: 10.1038/s41586-021-04265-w
pmc: PMC8810379
doi:

Substances chimiques

Anti-Bacterial Agents 0
Penicillins 0
beta-Lactams 0

Types de publication

Historical Article Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

135-141

Subventions

Organisme : Medical Research Council
ID : G1001787
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N002660/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P007201/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S00291X/1
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2022. The Author(s).

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Auteurs

Jesper Larsen (J)

Department of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark. jrl@ssi.dk.
ORCID: 0000-0003-0582-0457

Claire L Raisen (CL)

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Xiaoliang Ba (X)

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-3882-3585

Nicholas J Sadgrove (NJ)

Royal Botanic Gardens, Kew, Richmond, UK.

Guillermo F Padilla-González (GF)

Royal Botanic Gardens, Kew, Richmond, UK.
ORCID: 0000-0002-8300-6891

Monique S J Simmonds (MSJ)

Royal Botanic Gardens, Kew, Richmond, UK.

Igor Loncaric (I)

Institute of Microbiology, University of Veterinary Medicine, Vienna, Austria.

Heidrun Kerschner (H)

National Reference Center for Antimicrobial Resistance and Nosocomial Infections, Institute for Hygiene, Microbiology and Tropical Medicine, Ordensklinikum Linz Elisabethinen, Linz, Austria.

Petra Apfalter (P)

National Reference Center for Antimicrobial Resistance and Nosocomial Infections, Institute for Hygiene, Microbiology and Tropical Medicine, Ordensklinikum Linz Elisabethinen, Linz, Austria.

Rainer Hartl (R)

National Reference Center for Antimicrobial Resistance and Nosocomial Infections, Institute for Hygiene, Microbiology and Tropical Medicine, Ordensklinikum Linz Elisabethinen, Linz, Austria.

Ariane Deplano (A)

National Reference Centre-Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium.

Stien Vandendriessche (S)

National Reference Centre-Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium.
Laboratory for Medical Microbiology, Ghent University Hospital, Ghent, Belgium.

Barbora Černá Bolfíková (B)

Department of Animal Science and Food Processing, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Prague, Czech Republic.
ORCID: 0000-0001-8059-4889

Pavel Hulva (P)

Department of Zoology, Charles University, Prague, Czech Republic.
Department of Biology and Ecology, University of Ostrava, Ostrava, Czech Republic.

Maiken C Arendrup (MC)

Department of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.

Rasmus K Hare (RK)

Department of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.

Céline Barnadas (C)

Department of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.
European Programme for Public Health Microbiology Training (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.

Marc Stegger (M)

Department of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.

Raphael N Sieber (RN)

Department of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.

Robert L Skov (RL)

Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark.
ORCID: 0000-0002-6079-5381

Andreas Petersen (A)

Department of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.

Øystein Angen (Ø)

Department of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.

Sophie L Rasmussen (SL)

Department of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.
Wildlife Conservation Research Unit (WildCRU), Department of Zoology, University of Oxford, Tubney, UK.
ORCID: 0000-0002-2975-678X

Carmen Espinosa-Gongora (C)

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
ORCID: 0000-0002-9536-0548

Frank M Aarestrup (FM)

National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.
ORCID: 0000-0002-7116-2723

Laura J Lindholm (LJ)

Expert Microbiology Unit, Department of Health Security, Finnish Institute for Health and Welfare, Helsinki, Finland.

Suvi M Nykäsenoja (SM)

Microbiology Unit, Finnish Food Authority, Helsinki, Finland.

Frederic Laurent (F)

Bacteriology Department and French National Reference Center for Staphylococci, Hospices Civils de Lyon, University of Lyon, Lyon, France.

Karsten Becker (K)

Friedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
ORCID: 0000-0002-6391-1341

Birgit Walther (B)

Institute of Microbiology and Epizootics, Veterinary Faculty, Freie Universität Berlin, Berlin, Germany.
Advanced Light and Electron Microscopy (ZBS-4), Robert Koch Institute, Berlin, Germany.

Corinna Kehrenberg (C)

Institute for Veterinary Food Science, Justus-Liebig University Giessen, Giessen, Germany.

Christiane Cuny (C)

National Reference Centre for Staphylococci and Enterococci, Division Nosocomial Pathogens and Antibiotic Resistances, Department of Infectious Diseases, Robert Koch Institute, Wernigerode, Germany.

Franziska Layer (F)

National Reference Centre for Staphylococci and Enterococci, Division Nosocomial Pathogens and Antibiotic Resistances, Department of Infectious Diseases, Robert Koch Institute, Wernigerode, Germany.
ORCID: 0000-0002-4613-6478

Guido Werner (G)

National Reference Centre for Staphylococci and Enterococci, Division Nosocomial Pathogens and Antibiotic Resistances, Department of Infectious Diseases, Robert Koch Institute, Wernigerode, Germany.

Wolfgang Witte (W)

National Reference Centre for Staphylococci and Enterococci, Division Nosocomial Pathogens and Antibiotic Resistances, Department of Infectious Diseases, Robert Koch Institute, Wernigerode, Germany.

Ivonne Stamm (I)

Vet Med Labor GmbH, Kornwestheim, Germany.

Paolo Moroni (P)

Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Lodi, Italy.
Quality Milk Production Services, Animal Health Diagnostic Center, Cornell University, Ithaca, NY, USA.
ORCID: 0000-0002-0974-3084

Hannah J Jørgensen (HJ)

Norwegian Veterinary Institute, Ås, Norway.
ORCID: 0000-0002-1788-9219

Hermínia de Lencastre (H)

Laboratory of Molecular Genetics, ITQB NOVA, Oeiras, Portugal.
Laboratory of Microbiology and Infectious Diseases, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0001-6816-8932

Emilia Cercenado (E)

Servicio de Microbiología, Hospital Universitario Lucus Augusti, Lugo, Spain.
ORCID: 0000-0002-5279-3773

Fernando García-Garrote (F)

Servicio de Microbiología, Hospital Universitario Lucus Augusti, Lugo, Spain.
Servicio de Microbiología, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain.

Stefan Börjesson (S)

Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute (SVA), Uppsala, Sweden.
Department of Microbiology, Public Health Agency of Sweden, Solna, Sweden.
ORCID: 0000-0003-2219-2659

Sara Hæggman (S)

Department of Microbiology, Public Health Agency of Sweden, Solna, Sweden.

Vincent Perreten (V)

Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland.

Christopher J Teale (CJ)

Department of Bacteriology, Animal and Plant Health Agency, Weybridge, UK.

Andrew S Waller (AS)

Animal Health Trust, Newmarket, UK.
Intervacc AB, Stockholm, Stockholm, Sweden.
Department of Biomedical Science and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.
ORCID: 0000-0002-7111-9549

Bruno Pichon (B)

Antimicrobial Resistance and Healthcare Associated Infections Reference Unit, UK Health Security Agency, London, UK.

Martin D Curran (MD)

Clinical Microbiology and Public Health Laboratory, UK Health Security Agency, Addenbrooke's Hospital, Cambridge, UK.

Matthew J Ellington (MJ)

Clinical Microbiology and Public Health Laboratory, UK Health Security Agency, Addenbrooke's Hospital, Cambridge, UK.
Antimicrobial Resistance and Healthcare Associated Infections Reference Unit, UK Health Security Agency, London, UK.

John J Welch (JJ)

Department of Genetics, University of Cambridge, Cambridge, UK.

Sharon J Peacock (SJ)

Department of Medicine, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-1718-2782

David J Seilly (DJ)

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Fiona J E Morgan (FJE)

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Department of Physiology, Development & Neuroscience, University of Cambridge, Cambridge, UK.

Julian Parkhill (J)

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-7069-5958

Nazreen F Hadjirin (NF)

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Jodi A Lindsay (JA)

Institute of Infection and Immunity, St George's, University of London, London, UK.

Matthew T G Holden (MTG)

School of Medicine, University of St Andrews, St Andrews, UK.
ORCID: 0000-0002-4958-2166

Giles F Edwards (GF)

Scottish MRSA Reference Laboratory, NHS Greater Glasgow and Clyde, Stobhill Hospital, Glasgow, UK.

Geoffrey Foster (G)

SRUC Veterinary Services, Inverness, UK.
ORCID: 0000-0002-5527-758X

Gavin K Paterson (GK)

The Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush, UK.
ORCID: 0000-0002-1880-0095

Xavier Didelot (X)

School of Life Sciences and Department of Statistics, University of Warwick, Warwick, UK.
ORCID: 0000-0003-1885-500X

Mark A Holmes (MA)

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-5454-1625

Ewan M Harrison (EM)

Department of Medicine, University of Cambridge, Cambridge, UK.
Wellcome Sanger Institute, Hinxton, UK.
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-2720-0507

Anders R Larsen (AR)

Department of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Emergence of methicillin resistance predates...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Emergence of methicillin resistance predates...
questionsmedicales.fr › Eucaryotes › Champignons › Ascomycota › Onygenales › Arthrodermataceae › Emergence of methicillin resistance predates...
questionsmedicales.fr › Régions géographiques › Europe › Pays nordiques et scandinaves › Danemark › Emergence of methicillin resistance predates...
questionsmedicales.fr › Régions géographiques › Europe › Emergence of methicillin resistance predates...
questionsmedicales.fr › Phénomènes biologiques › Évolution biologique › Évolution moléculaire › Emergence of methicillin resistance predates...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse spatiale › Cartographie géographique › Emergence of methicillin resistance predates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Insectivora › Hérissons › Emergence of methicillin resistance predates...
questionsmedicales.fr › Sciences humaines › Histoire › Histoire moderne 1601- › Histoire du 20ème siècle › Emergence of methicillin resistance predates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Emergence of methicillin resistance predates...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Résistance aux bêta-lactamines › Résistance aux pénicillines › Résistance à la méticilline › Emergence of methicillin resistance predates...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus résistant à la méticilline › Emergence of methicillin resistance predates...
questionsmedicales.fr › Régions géographiques › Océanie › Australasie › Nouvelle-Zélande › Emergence of methicillin resistance predates...
questionsmedicales.fr › Caractéristiques de la population › Santé › Une seule santé › Emergence of methicillin resistance predates...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Pénicillines › Emergence of methicillin resistance predates...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Emergence of methicillin resistance predates...
questionsmedicales.fr › Phénomènes génétiques › Sélection génétique › Emergence of methicillin resistance predates...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Emergence of methicillin resistance predates...