The impact of bariatric surgery on serum tryptophan-kynurenine pathway metabolites.
Adult
Biomarkers
/ blood
Body Mass Index
Diabetes Mellitus, Type 2
/ blood
Female
Gastrectomy
Gastric Bypass
Glycated Hemoglobin
/ metabolism
Humans
Kynurenine
/ blood
Longitudinal Studies
Male
Middle Aged
Obesity
/ blood
Prospective Studies
Time Factors
Treatment Outcome
Tryptophan
/ blood
Xanthurenates
/ blood
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 01 2022
07 01 2022
Historique:
received:
28
05
2021
accepted:
03
12
2021
entrez:
8
1
2022
pubmed:
9
1
2022
medline:
25
2
2022
Statut:
epublish
Résumé
This study aims to explore the immediate effects of bariatric surgery on serum tryptophan-kynurenine pathway metabolites in individuals with type 2 diabetes and BMI > 30. With the goal of providing insight into the link between tryptophan pathway metabolites, type 2 diabetes, and chronic obesity-induced inflammation. This longitudinal study included 20 participants. Half were diagnosed with type 2 diabetes. 11 and 9 underwent RYGB and SG respectively. Blood samples were obtained at pre-operative and 3 months post-operative timepoints. Tryptophan and downstream metabolites of the kynurenine pathway were quantified with an ultrahigh-performance liquid chromatography tandem mass spectrometry with electrospray ionisation method. At 3 months post-operation, RYGB led to significant reductions in tryptophan, kynurenic acid and xanthurenic acid levels when compared to baseline. Significant reductions of the same metabolites after surgery were also observed in individuals with T2D irrespective of surgical procedure. These metabolites were significantly correlated with serum HbA1c levels and BMI. Bariatric surgery, in particular RYGB reduces serum levels of tryptophan and its downstream kynurenine metabolites. These metabolites are associated with T2D and thought to be potentially mechanistic in the systemic processes of obesity induced inflammation leading to insulin resistance. Its reduction after surgery is associated with an improvement in glycaemic control (HbA1c).
Identifiants
pubmed: 34996930
doi: 10.1038/s41598-021-03833-4
pii: 10.1038/s41598-021-03833-4
pmc: PMC8741964
doi:
Substances chimiques
Biomarkers
0
Glycated Hemoglobin A
0
Xanthurenates
0
hemoglobin A1c protein, human
0
Kynurenine
343-65-7
xanthurenic acid
58LAB1BG8J
Tryptophan
8DUH1N11BX
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
294Subventions
Organisme : Medical Research Council
ID : MC_PC_12025
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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