Palladium-Induced Temporal Internalization of MHC Class I Contributes to T Cell-Mediated Antigenicity.
Animals
Antigens
/ administration & dosage
CD8-Positive T-Lymphocytes
/ immunology
Cell Line
Cell Membrane
/ metabolism
Dendritic Cells
/ immunology
Drug Hypersensitivity
/ etiology
Female
Histocompatibility Antigens Class I
/ immunology
Humans
Lipopolysaccharides
/ administration & dosage
Mice
Mice, Inbred C57BL
Palladium
/ administration & dosage
Receptors, Antigen, T-Cell, alpha-beta
/ metabolism
MHC class I internalization
alternative peptide presentation
dental biomaterials
metal allergy
palladium
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
06
07
2021
accepted:
08
12
2021
entrez:
10
1
2022
pubmed:
11
1
2022
medline:
11
2
2022
Statut:
epublish
Résumé
Palladium (Pd) is a widely used metal and extremely important biomaterial for the reconstruction of occlusions during dental restorations. However, metallic biomaterials can cause serious allergic reactions, such as Pd-related oral mucositis seen in dentistry. Metal allergy is categorized as a type IV allergy and we demonstrated that CD8 T cells play an important role in Pd allergy previously. As TCR of CD8 T cells recognizes MHC class I/peptide complex, the antigen specificity to this complex seems to be generated during Pd allergy. However, it remains unknown if Pd affects the MHC class I/peptide complex. In this study, we investigated the behavior of the MHC class I/peptide complex in response to Pd treatment. We found that PdCl
Identifiants
pubmed: 35003059
doi: 10.3389/fimmu.2021.736936
pmc: PMC8732370
doi:
Substances chimiques
Antigens
0
Histocompatibility Antigens Class I
0
Lipopolysaccharides
0
Receptors, Antigen, T-Cell, alpha-beta
0
Palladium
5TWQ1V240M
palladium chloride
N9214IR8N7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
736936Informations de copyright
Copyright © 2021 Ito, Kanaseki, Tokita, Torigoe, Hirasawa and Ogasawara.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer N.S has declared a shared affiliation with some of the authors KI, NH, KO to the handling editor at the time of review.
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