Mapping Ambiphile Reactivity Trends in the Anti-(Hetero)annulation of Non-Conjugated Alkenes via Pd

alkene functionalization annulation directing group heterocycle palladium

Journal

Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543

Informations de publication

Date de publication:
21 03 2022
Historique:
received: 22 10 2021
pubmed: 11 1 2022
medline: 12 4 2022
entrez: 10 1 2022
Statut: ppublish

Résumé

In this study, we systematically evaluate different ambiphilic organohalides for their ability to participate in anti-selective carbo- or heteroannulation with non-conjugated alkenyl amides under Pd

Identifiants

pubmed: 35007393
doi: 10.1002/anie.202114346
pmc: PMC8923970
mid: NIHMS1771110
doi:

Substances chimiques

Alkenes 0
Pyrrolidines 0
Palladium 5TWQ1V240M

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202114346

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM125052
Pays : United States

Informations de copyright

© 2022 Wiley-VCH GmbH.

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Auteurs

Hui-Qi Ni (HQ)

Department of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA.

Phillippa Cooper (P)

Department of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA.

Shouliang Yang (S)

Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, CA 92121, USA.

Fen Wang (F)

Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, CA 92121, USA.

Neal Sach (N)

Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, CA 92121, USA.

Pranali G Bedekar (PG)

Department of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA.

Joyann S Donaldson (JS)

Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, CA 92121, USA.

Michelle Tran-Dubé (M)

Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, CA 92121, USA.

Indrawan J McAlpine (IJ)

Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, CA 92121, USA.

Keary M Engle (KM)

Department of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA.

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