Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?
B vitamins
cobalamin
energy metabolism
folate
heart failure
metabolic therapy
mitochondria
nicotinamide
pyridoxine
riboflavin
thiamin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Dec 2021
21 Dec 2021
Historique:
received:
03
11
2021
revised:
14
12
2021
accepted:
20
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
29
1
2022
Statut:
epublish
Résumé
Heart failure (HF) is a plague of the aging population in industrialized countries that continues to cause many deaths despite intensive research into more effective treatments. Although the therapeutic arsenal to face heart failure has been expanding, the relatively short life expectancy of HF patients is pushing towards novel therapeutic strategies. Heart failure is associated with drastic metabolic disorders, including severe myocardial mitochondrial dysfunction and systemic nutrient deprivation secondary to severe cardiac dysfunction. To date, no effective therapy has been developed to restore the cardiac energy metabolism of the failing myocardium, mainly due to the metabolic complexity and intertwining of the involved processes. Recent years have witnessed a growing scientific interest in natural molecules that play a pivotal role in energy metabolism with promising therapeutic effects against heart failure. Among these molecules, B vitamins are a class of water soluble vitamins that are directly involved in energy metabolism and are of particular interest since they are intimately linked to energy metabolism and HF patients are often B vitamin deficient. This review aims at assessing the value of B vitamin supplementation in the treatment of heart failure.
Identifiants
pubmed: 35008448
pii: ijms23010030
doi: 10.3390/ijms23010030
pmc: PMC8744601
pii:
doi:
Substances chimiques
Vitamin B Complex
12001-76-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : ERA-net Cardiovascular Diseases
ID : ANR-19-ECVD-0007-01
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