Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis.


Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
21 Dec 2021
Historique:
received: 30 11 2021
revised: 13 12 2021
accepted: 14 12 2021
entrez: 11 1 2022
pubmed: 12 1 2022
medline: 27 1 2022
Statut: epublish

Résumé

Whether the gut microbiome in obesity is characterized by lower diversity and altered composition at the phylum or genus level may be more accurately investigated using high-throughput sequencing technologies. We conducted a systematic review in PubMed and Embase including 32 cross-sectional studies assessing the gut microbiome composition by high-throughput sequencing in obese and non-obese adults. A significantly lower alpha diversity (Shannon index) in obese versus non-obese adults was observed in nine out of 22 studies, and meta-analysis of seven studies revealed a non-significant mean difference (-0.06, 95% CI -0.24, 0.12,

Identifiants

pubmed: 35010887
pii: nu14010012
doi: 10.3390/nu14010012
pmc: PMC8746372
pii:
doi:

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Federal Ministry of Food and Agriculture
ID : 01EA1906B

Références

BMC Genomics. 2015 Dec 12;16:1056
pubmed: 26651617
Nat Biotechnol. 2017 Nov;35(11):1077-1086
pubmed: 28967885
Int J Obes (Lond). 2008 Sep;32(9):1431-7
pubmed: 18607383
Int J Endocrinol. 2018 Mar 22;2018:4095789
pubmed: 29849617
Gut Microbes. 2020;11(1):63-76
pubmed: 31138061
Int J Surg. 2010;8(5):336-41
pubmed: 20171303
Microb Genom. 2021 Aug;7(8):
pubmed: 34356001
Nutr Today. 2016 Jul-Aug;51(4):167-174
pubmed: 27795585
NPJ Biofilms Microbiomes. 2019 Oct 4;5(1):28
pubmed: 31602309
Science. 2013 Sep 6;341(6150):1241214
pubmed: 24009397
Int J Med Microbiol. 2016 Aug;306(5):334-342
pubmed: 27052158
Cardiovasc Res. 2021 Feb 22;117(3):863-875
pubmed: 32374853
World J Pediatr. 2019 Aug;15(4):332-340
pubmed: 31134588
FEBS Lett. 2014 Nov 17;588(22):4223-33
pubmed: 25307765
BMC Microbiol. 2017 Jul 4;17(1):151
pubmed: 28676106
PLoS Comput Biol. 2021 Mar 30;17(3):e1008880
pubmed: 33784300
Nutrients. 2020 Jul 21;12(7):
pubmed: 32708278
Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15718-23
pubmed: 15505215
World J Gastrointest Pathophysiol. 2015 Nov 15;6(4):110-9
pubmed: 26600968
Front Microbiol. 2015 Aug 04;6:771
pubmed: 26300854
Sci Rep. 2018 Jun 27;8(1):9749
pubmed: 29950689
mBio. 2016 Aug 23;7(4):
pubmed: 27555308
Front Microbiol. 2018 Feb 14;9:213
pubmed: 29491857
Int J Obes (Lond). 2014 Dec;38(12):1525-31
pubmed: 24642959
Genome Biol. 2016 Sep 26;17(1):189
pubmed: 27666579
BMC Microbiol. 2020 Oct 31;20(1):330
pubmed: 33129264
Nature. 2006 Dec 21;444(7122):1022-3
pubmed: 17183309
Microorganisms. 2019 Jan 10;7(1):
pubmed: 30634578
PLoS One. 2019 Jul 24;14(7):e0215262
pubmed: 31339887
Biomed Res Int. 2017;2017:7585989
pubmed: 29214176
Int J Mol Sci. 2019 Jan 21;20(2):
pubmed: 30669548
Sci Rep. 2018 Jul 27;8(1):11356
pubmed: 30054529
Sci Rep. 2020 Nov 10;10(1):19417
pubmed: 33173145
Recent Results Cancer Res. 2016;208:1-15
pubmed: 27909899
Genes (Basel). 2020 Aug 03;11(8):
pubmed: 32756341
Genome Biol. 2019 Nov 1;20(1):219
pubmed: 31672155
PeerJ. 2016 Jan 07;4:e1514
pubmed: 26839739
Curr Oncol Rep. 2016 Jul;18(7):45
pubmed: 27255389
BMJ. 2016 Oct 12;355:i4919
pubmed: 27733354
OMICS. 2019 Oct;23(10):477-485
pubmed: 31589561
Eur J Clin Nutr. 2020 Sep;74(9):1251-1262
pubmed: 32231226
PLoS One. 2018 Jul 13;13(7):e0200305
pubmed: 30005082
Nutrients. 2020 May 19;12(5):
pubmed: 32438689
Curr Opin Gastroenterol. 2015 Jan;31(1):69-75
pubmed: 25394236
J Obes. 2013;2013:291546
pubmed: 24073332
Obesity (Silver Spring). 2013 Dec;21(12):E607-15
pubmed: 23526699
Int J Obes (Lond). 2018 Mar;42(3):424-432
pubmed: 29142244
PLoS One. 2020 Apr 29;15(4):e0230895
pubmed: 32348307
Curr Microbiol. 2018 Jun;75(6):726-735
pubmed: 29368026
Front Microbiol. 2018 Jun 22;9:1250
pubmed: 29988340
Nutr Clin Pract. 2015 Dec;30(6):787-97
pubmed: 26452391
Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11070-5
pubmed: 16033867
Nutr Diabetes. 2015 Apr 27;5:e153
pubmed: 25915742
J Sci Food Agric. 2021 Aug 18;:
pubmed: 34409603
PLoS One. 2016 Feb 05;11(2):e0148028
pubmed: 26849217
Front Microbiol. 2016 Dec 02;7:1945
pubmed: 27994578
Indian J Med Res. 2020 Jan;151(1):93-103
pubmed: 32134020
BMC Microbiol. 2018 Dec 12;18(1):210
pubmed: 30541450
BMC Gastroenterol. 2015 Aug 11;15:100
pubmed: 26261039
Cell Host Microbe. 2019 Aug 14;26(2):252-264.e10
pubmed: 31399369
Obes Res Clin Pract. 2020 Nov - Dec;14(6):524-530
pubmed: 33160863
Nature. 2017 Nov 23;551(7681):507-511
pubmed: 29143816
J Biosci. 2012 Sep;37(4):647-57
pubmed: 22922190
Trends Microbiol. 2016 Jul;24(7):523-524
pubmed: 26996766
Microbiologyopen. 2017 Aug;6(4):
pubmed: 28677210
Nature. 2020 May;581(7808):310-315
pubmed: 32433607
Nutrients. 2021 Feb 16;13(2):
pubmed: 33669303
PLoS One. 2014 Jan 08;9(1):e84689
pubmed: 24416266
J Clin Biochem Nutr. 2016 Jul;59(1):65-70
pubmed: 27499582
Genome Biol. 2017 Apr 13;18(1):70
pubmed: 28407784
Sci Rep. 2019 Sep 9;9(1):12918
pubmed: 31501492
Microorganisms. 2021 Jan 24;9(2):
pubmed: 33498853
Nat Commun. 2017 Dec 5;8(1):1784
pubmed: 29209090
Cancer Causes Control. 2017 Mar;28(3):247-258
pubmed: 28210884
Microbiome. 2016 Jun 21;4(1):28
pubmed: 27329048
Vasc Health Risk Manag. 2019 May 01;15:89-100
pubmed: 31118651
Cancer Epidemiol Biomarkers Prev. 2020 Nov;29(11):2289-2299
pubmed: 32855266

Auteurs

Mariona Pinart (M)

Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.

Andreas Dötsch (A)

Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institut (MRI)-Federal Research Institute of Nutrition and Food, 76131 Karlsruhe, Germany.

Kristina Schlicht (K)

Institute of Diabetes and Clinical Metabolic Research, University of Kiel, 24105 Kiel, Germany.

Matthias Laudes (M)

Institute of Diabetes and Clinical Metabolic Research, University of Kiel, 24105 Kiel, Germany.
Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine 1, Kiel University, 24118 Kiel, Germany.

Jildau Bouwman (J)

Microbiology and Systems Biology Group, Toegepast Natuurwetenschappelijk Onderzoek (TNO), Utrechtseweg 48, 3704 HE Zeist, The Netherlands.

Sofia K Forslund (SK)

Experimental and Clinical Research Center, A Cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany.
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117 Berlin, Germany.
Host-Microbiome Factors in Cardiovascular Disease Lab, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
Biobank Core Facility, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10178 Berlin, Germany.
German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, 10785 Berlin, Germany.

Tobias Pischon (T)

Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
Biobank Core Facility, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10178 Berlin, Germany.
German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, 10785 Berlin, Germany.
Biobank Technology Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.

Katharina Nimptsch (K)

Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.

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Classifications MeSH