Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 01 2022
10 01 2022
Historique:
received:
30
04
2021
accepted:
18
11
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
28
1
2022
Statut:
epublish
Résumé
Non-Ribosomal Peptide Synthetases (NRPSs) assemble a diverse range of natural products with important applications in both medicine and agriculture. They consist of several multienzyme subunits that must interact with each other in a highly controlled manner to facilitate efficient chain transfer, thus ensuring biosynthetic fidelity. Several mechanisms for chain transfer are known for NRPSs, promoting structural diversity. Herein, we report the first biochemically characterized example of a type II thioesterase (TE
Identifiants
pubmed: 35013184
doi: 10.1038/s41467-021-27512-0
pii: 10.1038/s41467-021-27512-0
pmc: PMC8748450
doi:
Substances chimiques
Fatty Acid Synthases
EC 2.3.1.85
Thiolester Hydrolases
EC 3.1.2.-
thioesterase II
EC 3.1.2.-
Peptide Synthases
EC 6.3.2.-
non-ribosomal peptide synthase
EC 6.3.2.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
62Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R00479X/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R01212/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M017982/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P003656/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R00479X/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R012121/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S00520X/1
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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