Effects of intracellular calcium accumulation on proteins encoded by the major genes underlying amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
/ genetics
Autophagy
C9orf72 Protein
/ genetics
Calcium
/ metabolism
Calcium Signaling
Calpain
/ metabolism
Caspases
/ metabolism
DNA-Binding Proteins
/ genetics
Gene Expression Regulation
HeLa Cells
Humans
Nerve Tissue Proteins
/ genetics
Neurons
/ metabolism
Nuclear Matrix-Associated Proteins
/ genetics
Profilins
/ genetics
Proteolysis
RNA-Binding Protein FUS
/ genetics
RNA-Binding Proteins
/ genetics
Sequestosome-1 Protein
/ genetics
Superoxide Dismutase-1
/ genetics
Time Factors
Transcriptome
Valosin Containing Protein
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 01 2022
10 01 2022
Historique:
received:
16
06
2021
accepted:
16
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
23
2
2022
Statut:
epublish
Résumé
The aetiology of Amyotrophic Lateral Sclerosis (ALS) is still poorly understood. The discovery of genetic forms of ALS pointed out the mechanisms underlying this pathology, but also showed how complex these mechanisms are. Excitotoxicity is strongly suspected to play a role in ALS pathogenesis. Excitotoxicity is defined as neuron damage due to excessive intake of calcium ions (Ca
Identifiants
pubmed: 35013445
doi: 10.1038/s41598-021-04267-8
pii: 10.1038/s41598-021-04267-8
pmc: PMC8748718
doi:
Substances chimiques
C9orf72 Protein
0
C9orf72 protein, human
0
DNA-Binding Proteins
0
FUS protein, human
0
MATR3 protein, human
0
Nerve Tissue Proteins
0
Nuclear Matrix-Associated Proteins
0
PFN1 protein, human
0
Profilins
0
RNA-Binding Protein FUS
0
RNA-Binding Proteins
0
SOD1 protein, human
0
SQSTM1 protein, human
0
Sequestosome-1 Protein
0
TARDBP protein, human
0
Superoxide Dismutase-1
EC 1.15.1.1
Calpain
EC 3.4.22.-
Caspases
EC 3.4.22.-
VCP protein, human
EC 3.6.4.6
Valosin Containing Protein
EC 3.6.4.6
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
395Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : 2017SNW5MB
Organisme : Ministero della Salute
ID : RF-2016-02362405
Organisme : Ministero della Salute
ID : RF-2018-12365614
Informations de copyright
© 2022. The Author(s).
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