Theoretical evidence of osteoblast self-inhibition after activation of the genetic regulatory network controlling mineralization.

Calcification, Physiologic / genetics Cell Differentiation Gene Expression Regulation Gene Regulatory Networks Osteoblasts Transcription Factors / metabolism
Bone Genetic network Hill functions Nonlinear differential equations

Journal

Journal of theoretical biology
ISSN: 1095-8541
Titre abrégé: J Theor Biol
Pays: England
ID NLM: 0376342

Informations de publication

Date de publication:
21 03 2022
Historique:
received: 21 04 2021
revised: 23 12 2021
accepted: 03 01 2022
pubmed: 16 1 2022
medline: 1 4 2022
entrez: 15 1 2022
Statut: ppublish

Résumé

Bone is a hard-soft biomaterial built through a self-assembly process under genetic regulatory network (GRN) monitoring. This paper aims to capture the behavior of the bone GRN part that controls mineralization by using a mathematical model. Here, we provide an advanced review of empirical evidence about interactions between gene coding (i) transcription factors and (ii) bone proteins. These interactions are modeled with nonlinear differential equations using Michaelis-Menten and Hill functions. Compared to empirical evidence - coming from osteoblasts culture -, the two best systems (among 12

Identifiants

DOI: 10.1016/j.jtbi.2022.111005 PMID: 35031309
pubmed: 35031309
pii: S0022-5193(22)00003-0
doi: 10.1016/j.jtbi.2022.111005
pii:
doi:

Substances chimiques

Transcription Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111005

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Abdennasser Chekroun (A)

Laboratoire d'Analyse Non Linéaire et Mathématiques Appliquées, University of Tlemcen, Chetouane 13000, Algeria; Univ Lyon, Inria, Université Claude Bernard Lyon 1, CNRS UMR5208, Institut Camille Jordan, F-69603 Villeurbanne, France.

Laurent Pujo-Menjouet (L)

Univ Lyon, Inria, Université Claude Bernard Lyon 1, CNRS UMR5208, Institut Camille Jordan, F-69603 Villeurbanne, France. Electronic address: pujo@math.univ-lyon1.fr.

Steve Falcoz (S)

Univ Lyon, Inria, Université Claude Bernard Lyon 1, CNRS UMR5208, Institut Camille Jordan, F-69603 Villeurbanne, France; Department of Physical Therapy, College of Staten Island, City University of New York, New York, NY 10314, USA.

Kamyine Tsuen (K)

Department of Physical Therapy, College of Staten Island, City University of New York, New York, NY 10314, USA; Nanoscience Initiative, Advance Science Research Center, City University of New York, New York, NY 10031, USA.

Kevin Yueh-Hsun Yang (K)

New York Center for Biomedical Engineering, City College of New York, City University of New York, New York, NY 10031, USA.

Jean-Philippe Berteau (JP)

Department of Physical Therapy, College of Staten Island, City University of New York, New York, NY 10314, USA; New York Center for Biomedical Engineering, City College of New York, City University of New York, New York, NY 10031, USA; Nanoscience Initiative, Advance Science Research Center, City University of New York, New York, NY 10031, USA.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Calcification physiologique › Theoretical evidence of osteoblast...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Theoretical evidence of osteoblast...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Theoretical evidence of osteoblast...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Réseaux de régulation génique › Theoretical evidence of osteoblast...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Theoretical evidence of osteoblast...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Theoretical evidence of osteoblast...