RNA thermometers and other regulatory elements: Diversity and importance in bacterial pathogenesis.


Journal

Wiley interdisciplinary reviews. RNA
ISSN: 1757-7012
Titre abrégé: Wiley Interdiscip Rev RNA
Pays: United States
ID NLM: 101536955

Informations de publication

Date de publication:
09 2022
Historique:
revised: 09 11 2021
received: 07 08 2021
accepted: 16 12 2021
pubmed: 18 1 2022
medline: 14 9 2022
entrez: 17 1 2022
Statut: ppublish

Résumé

Survival of microorganisms depends to a large extent on environmental conditions and the occupied host. By adopting specific strategies, microorganisms can thrive in the surrounding environment and, at the same time, preserve their viability. Evading the host defenses requires several mechanisms compatible with the host survival which include the production of RNA thermometers to regulate the expression of genes responsible for heat or cold shock as well as of those involved in virulence. Microorganisms have developed a variety of molecules in response to the environmental changes in temperature and even more specifically to the host they invade. Among all, RNA-based regulatory mechanisms are the most common ones, highlighting the importance of such molecules in gene expression control and novel drug development by suitable structure-based alterations. This article is categorized under: RNA Structure and Dynamics > RNA Structure, Dynamics and Chemistry RNA in Disease and Development > RNA in Disease RNA Structure and Dynamics > Influence of RNA Structure in Biological Systems.

Identifiants

pubmed: 35037405
doi: 10.1002/wrna.1711
doi:

Substances chimiques

RNA, Bacterial 0
RNA 63231-63-0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1711

Informations de copyright

© 2022 Wiley Periodicals LLC.

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Auteurs

Akanksha Sharma (A)

Department of Biophysics, Panjab University, Chandigarh, India.
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.

Hema Kumari Alajangi (HK)

Department of Biophysics, Panjab University, Chandigarh, India.
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.

Giuseppina Pisignano (G)

Department of Biology and Biochemistry, University of Bath, Bath, UK.

Vikas Sood (V)

Department of Biochemistry, Jamia Hamdard, New Delhi, India.

Gurpal Singh (G)

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.

Ravi Pratap Barnwal (RP)

Department of Biophysics, Panjab University, Chandigarh, India.

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