Pentobarbital may protect against neurogenic inflammation after surgery via inhibition of substance P release from peripheral nerves of rats.
Analgesics
/ pharmacology
Animals
Anti-Inflammatory Agents
/ pharmacology
Calcium Channels
/ metabolism
Capsaicin
/ pharmacology
Cells, Cultured
Ganglia, Spinal
/ drug effects
Ketamine
/ pharmacology
Male
Neurogenic Inflammation
/ drug therapy
Pentobarbital
/ pharmacology
Peripheral Nerves
/ drug effects
Rats
Rats, Wistar
Sensory System Agents
/ pharmacology
Substance P
/ metabolism
TRPV Cation Channels
/ metabolism
Anti-Inflammatory Effect
Barbiturate
Capsaicin
Ketamine
Neurogenic Inflammation
Substance P
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
06 02 2022
06 02 2022
Historique:
received:
31
03
2020
revised:
28
12
2021
accepted:
15
01
2022
pubmed:
23
1
2022
medline:
15
3
2022
entrez:
22
1
2022
Statut:
ppublish
Résumé
The inflammatory response related to surgery is considered surgical inflammation. Most anesthetic agents directly or indirectly suppress the immune response. However, the intravenous anesthetics pentobarbital and ketamine were reported to inhibit the lipopolysaccharide-induced inflammatory response such as cytokines formation. Neurogenic inflammation is inflammation originating from the local release of inflammatory mediators, such as substance P (SP), by primary afferent neurons after noxious stimuli like surgery. Thus, in this study, we examined whether pentobarbital and ketamine suppress SP release from cultured dorsal root ganglion (DRG) neurons. DRG cells were dissected from male Wistar rats. Released SP was measured by radioimmunoassay. We demonstrated that higher concentrations of pentobarbital (100-1,000 μM) significantly inhibited capsaicin (100 nM)-induced, but not high K
Identifiants
pubmed: 35063502
pii: S0304-3940(22)00024-6
doi: 10.1016/j.neulet.2022.136467
pii:
doi:
Substances chimiques
Analgesics
0
Anti-Inflammatory Agents
0
Calcium Channels
0
Sensory System Agents
0
TRPV Cation Channels
0
Trpv1 protein, rat
0
Substance P
33507-63-0
Ketamine
690G0D6V8H
Pentobarbital
I4744080IR
Capsaicin
S07O44R1ZM
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
136467Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.