The effect of prophylactic use of tranexamic acid for cesarean section.


Journal

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
ISSN: 1476-4954
Titre abrégé: J Matern Fetal Neonatal Med
Pays: England
ID NLM: 101136916

Informations de publication

Date de publication:
Dec 2022
Historique:
pubmed: 25 1 2022
medline: 24 11 2022
entrez: 24 1 2022
Statut: ppublish

Résumé

Treatment with tranexamic acid (TxA) significantly reduces maternal death due to postpartum hemorrhage. There is increasing interest in whether it can also be used as prophylaxis for postpartum hemorrhage, especially during cesarean sections (CS). This impact study is aimed to determine the effect of routine prophylactic tranexamic acid during CS on maternal hemorrhage and the rate of the associated side effects. This retrospective population-based cohort single-center impact study include 2000 women who delivered by CS divided into two groups with ( Women who did not receive TxA prophylactic had a higher rate of >10% hemoglobin decrease and a higher rate of ≥2 g/dL hemoglobin decrease Than those who received TxA prophylaxis ( The finding of our study suggest that prophylactic administration of TxA prior to CS improves maternal and neonatal outcomes.

Identifiants

pubmed: 35068314
doi: 10.1080/14767058.2021.2019215
doi:

Substances chimiques

Tranexamic Acid 6T84R30KC1
Antifibrinolytic Agents 0
Hemoglobins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

9157-9162

Auteurs

Yair Binyamin (Y)

Department of Anesthesiology, Soroka University Medical Center, Beer-Sheva, Israel.
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Sharon Orbach-Zinger (S)

Department of Anesthesia, Beilinson Hospital, Rabin Medical Center associated with Sakler Medical School, Tel Aviv University, Tel Aviv, Israel.

Igor Gruzman (I)

Department of Anesthesiology, Soroka University Medical Center, Beer-Sheva, Israel.
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Amit Frenkel (A)

Department of Anesthesiology, Soroka University Medical Center, Beer-Sheva, Israel.
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Sofia Lerman (S)

Department of Anesthesiology, Soroka University Medical Center, Beer-Sheva, Israel.
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Alexander Zlotnik (A)

Department of Anesthesiology, Soroka University Medical Center, Beer-Sheva, Israel.
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Dmitry Frank (D)

Department of Anesthesiology, Soroka University Medical Center, Beer-Sheva, Israel.
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Alexander Ioscovich (A)

Department of Anesthesiology, Perioperative Medicine and Pain Treatment, Shaare Zedek Medical Center, Hebrew University Hadassah Medical School, Jerusalem, Israel.

Offer Erez (O)

Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Maternity Department "D", Division of Obstetrics and Gynecology, Soroka University Medical Center, Beer-Sheva, Israel.
Department of Obstetrics and Gynecology, Hutzel Women's Hospital, School of Medicine, Wayne State University, Detroit, MI, USA.

Michael Heesen (M)

Department of Anesthesia, Kantonsspital Baden, Baden, Switzerland.

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Classifications MeSH