Enhanced mechanical properties and biocompatibility on BC/HAp composite through calcium gluconate fortified bacterial.

Bacteria Calcium Gluconate / pharmacology Cellulose / chemistry Durapatite / chemistry Tissue Engineering / methods
Bacterial cellulose Biomineralization Calcium gluconate Hydroxyapatite In situ biosynthesis

Journal

Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156

Informations de publication

Date de publication:
01 Apr 2022
Historique:
received: 18 09 2021
revised: 27 12 2021
accepted: 29 12 2021
entrez: 25 1 2022
pubmed: 26 1 2022
medline: 8 4 2022
Statut: ppublish

Résumé

Bacterial cellulose/hydroxyapatite (BC/HAp) composite is an outstanding candidate for bone tissue engineering. The conventional biomimetic mineralization method takes a long time with unsatisfactory mechanical properties and biocompatibility. Herein, we modified the BC by changing the carbon source to calcium gluconate during the biosynthesis process of BC by bacteria, providing nucleation sites for further mineralization in simulated body fluid. Results show spherical porous HAp in the size of 100-200 nm was fully filled in the three-dimensional network structure of BC nanofibers uniformly within five days of mineralization. Molecular dynamics simulation shows that the aggregation of cellulose units in aqueous solution can enhance the adsorption of calcium ions. By this means, we significantly improved the mechanical properties and biocompatibility of the BC/HAp composite, as well as simplified the preparation process, compared to conventional method, which, therefore, suggests, it could be further studied for biomedical applications such as bone tissue engineering.

Identifiants

DOI: 10.1016/j.carbpol.2021.119085 PMID: 35074101
pubmed: 35074101
pii: S0144-8617(21)01472-7
doi: 10.1016/j.carbpol.2021.119085
pii:
doi:

Substances chimiques

Cellulose 9004-34-6
Durapatite 91D9GV0Z28
Calcium Gluconate SQE6VB453K

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

119085

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Lin Shi (L)

Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing 210094, China.

Tao Wang (T)

Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing 210094, China.

Lei Yang (L)

Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing 210094, China.

Chuntao Chen (C)

Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing 210094, China. Electronic address: chchunt@njust.edu.cn.

Ran Dou (R)

Computational Institute for Molecules and Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing 210094, China.

Xiaoli Yang (X)

Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing 210094, China.

Bianjing Sun (B)

Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing 210094, China.

Baojing Zhou (B)

Computational Institute for Molecules and Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing 210094, China.

Lei Zhang (L)

Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing 210094, China. Electronic address: leizhang@njust.edu.cn.

Dongping Sun (D)

Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing 210094, China. Electronic address: hysdp@njust.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Bactéries › Enhanced mechanical properties and...
questionsmedicales.fr › Glucides › Oses acides › Gluconates › Gluconate de calcium › Enhanced mechanical properties and...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Biopolymères › Cellulose › Enhanced mechanical properties and...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Phosphates de calcium › Apatites › Hydroxyapatites › Durapatite › Enhanced mechanical properties and...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Ingénierie tissulaire › Enhanced mechanical properties and...