Differential Orthopedia Homeobox expression in pulmonary carcinoids is associated with changes in DNA methylation.
Orthopedia Homeobox
epigenetics
methylation
neuroendocrine
pulmonary carcinoid
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 06 2022
15 06 2022
Historique:
revised:
26
11
2021
received:
03
08
2021
accepted:
03
01
2022
pubmed:
26
1
2022
medline:
20
4
2022
entrez:
25
1
2022
Statut:
ppublish
Résumé
Limited number of tumor types have been examined for Orthopedia Homeobox (OTP) expression. In pulmonary carcinoids, loss of expression is a strong indicator of poor prognosis. Here, we investigated OTP expression in 37 different tumor types, and the association between OTP expression and DNA methylation levels in lung neuroendocrine neoplasms. We analyzed publicly available multi-omics data (whole-exome-, whole-genome-, RNA sequencing and Epic 850K-methylation array) of 58 typical carcinoids, 27 atypical carcinoids, 69 large cell neuroendocrine carcinoma and 51 small cell lung cancer patients and TCGA (The Cancer Genome Atlas) data of 33 tumor types. 850K-methylation analysis was cross-validated using targeted pyrosequencing on 35 carcinoids. We report bimodality of OTP expression in carcinoids (OTP
Identifiants
pubmed: 35076935
doi: 10.1002/ijc.33939
pmc: PMC9303689
doi:
Substances chimiques
Biomarkers, Tumor
0
Homeodomain Proteins
0
Nerve Tissue Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1987-1997Informations de copyright
© 2022 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
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