Experimental evidence for a child-to-adolescent switch in human amygdala-prefrontal cortex communication: A cross-sectional pilot study.
amygdala
brain development
connectivity
emotion regulation
fMRI
prefrontal cortex
Journal
Developmental science
ISSN: 1467-7687
Titre abrégé: Dev Sci
Pays: England
ID NLM: 9814574
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
20
12
2021
received:
23
09
2020
accepted:
02
01
2022
pubmed:
27
1
2022
medline:
22
6
2022
entrez:
26
1
2022
Statut:
ppublish
Résumé
Interactions between the amygdala and prefrontal cortex are fundamental to human emotion. Despite the central role of frontoamygdala communication in adult emotional learning and regulation, little is known about how top-down control emerges during human development. In the present cross-sectional pilot study, we experimentally manipulated prefrontal engagement to test its effects on the amygdala during development. Inducing dorsal anterior cingulate cortex (dACC) activation resulted in developmentally-opposite effects on amygdala reactivity during childhood versus adolescence, such that dACC activation was followed by increased amygdala reactivity in childhood but reduced amygdala reactivity in adolescence. Bayesian network analyses revealed an age-related switch between childhood and adolescence in the nature of amygdala connectivity with the dACC and ventromedial PFC (vmPFC). Whereas adolescence was marked by information flow from dACC and vmPFC to amygdala (consistent with that observed in adults), the reverse information flow, from the amygdala to dACC and vmPFC, was dominant in childhood. The age-related switch in information flow suggests a potential shift from bottom-up co-excitatory to top-down regulatory frontoamygdala connectivity and may indicate a profound change in the circuitry supporting maturation of emotional behavior. These findings provide novel insight into the developmental construction of amygdala-cortical connections and implications for the ways in which childhood experiences may influence subsequent prefrontal function.
Identifiants
pubmed: 35080089
doi: 10.1111/desc.13238
pmc: PMC9232876
mid: NIHMS1775595
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13238Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIMH NIH HHS
ID : R15MH122927
Pays : United States
Organisme : NIH HHS
ID : DP5 OD021370
Pays : United States
Organisme : CSRD VA
ID : IK2 CX001916
Pays : United States
Organisme : National Institutes of Health (NIH Director's Early Independence Award
ID : DP5OD021370
Organisme : NIMH NIH HHS
ID : R01 MH091864
Pays : United States
Informations de copyright
© 2022 John Wiley & Sons Ltd.
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