Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
28 01 2022
Historique:
entrez: 26 1 2022
pubmed: 27 1 2022
medline: 20 4 2022
Statut: ppublish

Résumé

Human endogenous retroviruses (HERVs) represent 8% of the human genome. HERV products may represent tumor antigens relevant for cancer immunotherapy. We developed a bioinformatic approach to identify shared CD8

Identifiants

pubmed: 35080970
doi: 10.1126/sciadv.abj3671
pmc: PMC8791462
doi:

Substances chimiques

Epitopes, T-Lymphocyte 0
HLA-A2 Antigen 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabj3671

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Auteurs

Paola Bonaventura (P)

Centre de Recherche en Cancérologie de Lyon (CRCL), UMR INSERM U1052 CNRS 5286, Lyon, France.
Centre Léon Bérard, Lyon, France.

Vincent Alcazer (V)

Centre de Recherche en Cancérologie de Lyon (CRCL), UMR INSERM U1052 CNRS 5286, Lyon, France.

Virginie Mutez (V)

ErVaccine Technologies, Lyon, France.

Laurie Tonon (L)

Synergie Lyon Cancer, Plateforme de bioinformatique « Gilles Thomas », Lyon, France.

Juliette Martin (J)

CNRS-Institut de Biologie et Chimie des Protéines UMR 5086, Lyon, France.

Nicolas Chuvin (N)

ErVaccine Technologies, Lyon, France.

Emilie Michel (E)

ErVaccine Technologies, Lyon, France.

Rasha E Boulos (RE)

ErVaccine Technologies, Lyon, France.

Yann Estornes (Y)

ErVaccine Technologies, Lyon, France.

Jenny Valladeau-Guilemond (J)

Centre de Recherche en Cancérologie de Lyon (CRCL), UMR INSERM U1052 CNRS 5286, Lyon, France.

Alain Viari (A)

Synergie Lyon Cancer, Plateforme de bioinformatique « Gilles Thomas », Lyon, France.

Qing Wang (Q)

Complete Omics, Baltimore, MD, USA.

Christophe Caux (C)

Centre de Recherche en Cancérologie de Lyon (CRCL), UMR INSERM U1052 CNRS 5286, Lyon, France.
Centre Léon Bérard, Lyon, France.

Stéphane Depil (S)

Centre de Recherche en Cancérologie de Lyon (CRCL), UMR INSERM U1052 CNRS 5286, Lyon, France.
Centre Léon Bérard, Lyon, France.
ErVaccine Technologies, Lyon, France.
Université Claude Bernard Lyon 1, Lyon, France.

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Classifications MeSH