Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases.
3T3-L1 Cells
Anacardic Acids
/ chemical synthesis
Anacardium
/ chemistry
Animals
Drug Design
Gene Expression
/ drug effects
HEK293 Cells
Humans
Lipid Metabolism
/ drug effects
Male
Mice
Mice, Inbred C57BL
Molecular Docking Simulation
Nuts
/ chemistry
PPAR alpha
/ agonists
PPAR delta
/ agonists
PPAR gamma
/ agonists
Protein Domains
Zebrafish
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
10 02 2022
10 02 2022
Historique:
pubmed:
29
1
2022
medline:
23
2
2022
entrez:
28
1
2022
Statut:
ppublish
Résumé
Metabolic diseases are increasing at staggering rates globally. The peroxisome proliferator-activated receptors (PPARα/γ/δ) are fatty acid sensors that help mitigate imbalances between energy uptake and utilization. Herein, we report compounds derived from phenolic lipids present in cashew nut shell liquid (CNSL), an abundant waste byproduct, in an effort to create effective, accessible, and sustainable drugs. Derivatives of anacardic acid and cardanol were tested for PPAR activity in HEK293 cell co-transfection assays, primary hepatocytes, and 3T3-L1 adipocytes.
Identifiants
pubmed: 35089724
doi: 10.1021/acs.jmedchem.1c01542
doi:
Substances chimiques
Anacardic Acids
0
PPAR alpha
0
PPAR delta
0
PPAR gamma
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM