David Uehling

Affiliations

Drug Discovery Program, Ontario Institute for Cancer Research, Ontario, Canada.

Publications (12)

Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.

Journal of molecular biology

Avec: Punit Saraon , Jamie Snider , Wiebke Schormann , Ankit Rai , Nikolina Radulovich , Maria Sánchez-Osuna , Jasmin Coulombe-Huntington , Caroline Huard , Mohammed Mohammed , Evelyne Lima-Fernandes , Brigitte Thériault , Levon Halabelian , Manuel Chan , Dhananjay Joshi , Luka Drecun , Zhong Yao , Shivanthy Pathmanathan , Victoria Wong , Anna Lyakisheva , Farzaneh Aboualizadeh , Li Niu , Fengling Li , Taira Kiyota , Ratheesh Subramanian , Babu Joseph , Ahmed Aman , Michael Prakesch , Methvin Isaac , Ahmed Mamai , Gennady Poda , Masoud Vedadi , Richard Marcellus , David Uehling , Natasha Leighl , Adrian Sacher , Miroslav Samaržija , Marko Jakopović , Cheryl Arrowsmith , Mike Tyers , Ming-Sound Tsao , David Andrews , Rima Al-Awar , Igor Stagljar

Targeting tumour-associated macrophages in hodgkin lymphoma using engineered extracellular matrix-mimicking cryogels.

Biomaterials

Avec: Laura C Bahlmann , Chang Xue , Allysia A Chin , Arianna Skirzynska , Joy Lu , Brigitte Thériault , David Uehling , Yulia Yerofeyeva , Rachel Peters , Kela Liu , Jianan Chen , Anne L Martel , Martin Yaffe , Rima Al-Awar , Rashmi S Goswami , Jarkko Ylanko , David W Andrews , John Kuruvilla , Rob C Laister , Molly S Shoichet

Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Yi Liang , Sujeeve Jeganathan , Stefano Marastoni , Adam Sharp , Ines Figueiredo , Richard Marcellus , Amanda Mawson , Zvi Shalev , Aleksandra Pesic , Joan Sweet , Haiyang Guo , David Uehling , Bora Gurel , Antje Neeb , Housheng Hansen He , Bruce Montgomery , Marianne Koritzinsky , Samantha Oakes , Johann S de Bono , Martin Gleave , Amina Zoubeidi , Bradly G Wouters , Anthony M Joshua

An effective kinase inhibition strategy for metastatic recurrent childhood medulloblastoma.

Journal of neuro-oncology

Avec: Ashley A Adile , David Bakhshinyan , Yujin Suk , David Uehling , Mehakpreet Saini , Ahmed Aman , Jakob Magolan , Minomi K Subapanditha , Dillon McKenna , Chirayu Chokshi , Neil Savage , Michelle M Kameda-Smith , Chitra Venugopal , Sheila K Singh

Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases.

Journal of medicinal chemistry

Avec: Cigdem Sahin , Lilia Magomedova , Thais A M Ferreira , Jiabao Liu , Jens Tiefenbach , Priscilla S Alves , Fellipe J G Queiroz , Andressa S de Oliveira , Mousumi Bhattacharyya , Julie Grouleff , Patrícia C N Nogueira , Edilberto R Silveira , Daniel C Moreira , José Roberto Souza de Almeida Leite , Guilherme D Brand , David Uehling , Gennady Poda , Henry Krause , Carolyn L Cummins , Luiz A S Romeiro

Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation.

Cancer discovery

Avec: Mary M Mader , Joachim Rudolph , Ingo V Hartung , David Uehling , Paul Workman , William Zuercher

Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport.

The Journal of biological chemistry

Avec: Qiangmin Zhang , Kunhong Xiao , José M Paredes , Tatyana Mamonova , W Bruce Sneddon , Hongda Liu , Dawei Wang , Sheng Li , Jennifer C McGarvey , David Uehling , Rima Al-Awar , Babu Joseph , Frederic Jean-Alphonse , Angel Orte , Peter A Friedman

A drug discovery platform to identify compounds that inhibit EGFR triple mutants.

Nature chemical biology

Avec: Punit Saraon , Jamie Snider , Yannis Kalaidzidis , Leanne E Wybenga-Groot , Konstantin Weiss , Ankit Rai , Nikolina Radulovich , Luka Drecun , Nika Vučković , Adriana Vučetić , Victoria Wong , Brigitte Thériault , Nhu-An Pham , Jin H Park , Alessandro Datti , Jenny Wang , Shivanthy Pathmanathan , Farzaneh Aboualizadeh , Anna Lyakisheva , Zhong Yao , Yuhui Wang , Babu Joseph , Ahmed Aman , Michael F Moran , Michael Prakesch , Gennady Poda , Richard Marcellus , David Uehling , Miroslav Samaržija , Marko Jakopović , Ming-Sound Tsao , Frances A Shepherd , Adrian Sacher , Natasha Leighl , Anna Akhmanova , Rima Al-Awar , Marino Zerial , Igor Stagljar

Functional characterization of a PROTAC directed against BRAF mutant V600E.

Nature chemical biology

Avec: Ganna Posternak , Xiaojing Tang , Pierre Maisonneuve , Ting Jin , Hugo Lavoie , Salima Daou , Stephen Orlicky , Theo Goullet de Rugy , Lauren Caldwell , Kin Chan , Ahmed Aman , Michael Prakesch , Gennady Poda , Pavel Mader , Cassandra Wong , Stefan Maier , Julia Kitaygorodsky , Brett Larsen , Karen Colwill , Zhe Yin , Derek F Ceccarelli , Robert A Batey , Mikko Taipale , Igor Kurinov , David Uehling , Jeff Wrana , Daniel Durocher , Anne-Claude Gingras , Rima Al-Awar , Marc Therrien , Frank Sicheri

Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma.

Journal of medicinal chemistry

Avec: David Smil , Jong Fu Wong , Eleanor P Williams , Roslin J Adamson , Alison Howarth , David A McLeod , Ahmed Mamai , Soyoung Kim , Brian J Wilson , Taira Kiyota , Ahmed Aman , Julie Owen , Gennady Poda , Kurumi Y Horiuchi , Ekaterina Kuznetsova , Haiching Ma , J Nicole Hamblin , Sue Cramp , Owen G Roberts , Aled M Edwards , David Uehling , Rima Al-Awar , Alex N Bullock , Jeff A O'Meara , Methvin B Isaac

The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia.

Oncoimmunology

Avec: Maria I Edilova , Jaclyn C Law , Safoura Zangiabadi , Kenneth Ting , Achire N Mbanwi , Andrea Arruda , David Uehling , Methvin Isaac , Michael Prakesch , Rima Al-Awar , Mark D Minden , Ali A Abdul-Sater , Tania H Watts

Pharmacological Targeting of Executioner Proteins: Controlling Life and Death.

Journal of medicinal chemistry

Avec: Justin P Pogmore , David Uehling , David W Andrews

Réseau de co-auteurs

Rima Al-Awar 7 collaborations

Ahmed Aman 5 collaborations

Gennady Poda 5 collaborations

Michael Prakesch 4 collaborations

Brigitte Thériault 3 collaborations

Babu Joseph 3 collaborations

Richard Marcellus 3 collaborations

Punit Saraon 2 collaborations

Jamie Snider 2 collaborations

Ankit Rai 2 collaborations

Nikolina Radulovich 2 collaborations

Luka Drecun 2 collaborations

Zhong Yao 2 collaborations

Shivanthy Pathmanathan 2 collaborations

Victoria Wong 2 collaborations

Anna Lyakisheva 2 collaborations

Farzaneh Aboualizadeh 2 collaborations

Taira Kiyota 2 collaborations

Methvin Isaac 2 collaborations

Ahmed Mamai 2 collaborations

Natasha Leighl 2 collaborations

Adrian Sacher 2 collaborations

Miroslav Samaržija 2 collaborations

Marko Jakopović 2 collaborations

Ming-Sound Tsao 2 collaborations

Igor Stagljar 2 collaborations

David W Andrews 2 collaborations

Wiebke Schormann 1 collaboration

Maria Sánchez-Osuna 1 collaboration

Jasmin Coulombe-Huntington 1 collaboration

Caroline Huard 1 collaboration

Mohammed Mohammed 1 collaboration

Evelyne Lima-Fernandes 1 collaboration

Levon Halabelian 1 collaboration

Manuel Chan 1 collaboration

Dhananjay Joshi 1 collaboration

Li Niu 1 collaboration

Fengling Li 1 collaboration

Ratheesh Subramanian 1 collaboration

Masoud Vedadi 1 collaboration

Cheryl Arrowsmith 1 collaboration

Mike Tyers 1 collaboration

David Andrews 1 collaboration

Laura C Bahlmann 1 collaboration

Chang Xue 1 collaboration

Allysia A Chin 1 collaboration

Arianna Skirzynska 1 collaboration

Joy Lu 1 collaboration

Yulia Yerofeyeva 1 collaboration

Rachel Peters 1 collaboration

Kela Liu 1 collaboration

Jianan Chen 1 collaboration

Anne L Martel 1 collaboration

Martin Yaffe 1 collaboration

Rashmi S Goswami 1 collaboration

Jarkko Ylanko 1 collaboration

John Kuruvilla 1 collaboration

Rob C Laister 1 collaboration

Molly S Shoichet 1 collaboration

Yi Liang 1 collaboration

Sujeeve Jeganathan 1 collaboration

Stefano Marastoni 1 collaboration

Adam Sharp 1 collaboration

Ines Figueiredo 1 collaboration

Amanda Mawson 1 collaboration

Zvi Shalev 1 collaboration

Aleksandra Pesic 1 collaboration

Joan Sweet 1 collaboration

Haiyang Guo 1 collaboration

Bora Gurel 1 collaboration

Antje Neeb 1 collaboration

Housheng Hansen He 1 collaboration

Bruce Montgomery 1 collaboration

Marianne Koritzinsky 1 collaboration

Samantha Oakes 1 collaboration

Johann S de Bono 1 collaboration

Martin Gleave 1 collaboration

Amina Zoubeidi 1 collaboration

Bradly G Wouters 1 collaboration

Anthony M Joshua 1 collaboration

Ashley A Adile 1 collaboration

David Bakhshinyan 1 collaboration

Yujin Suk 1 collaboration

Mehakpreet Saini 1 collaboration

Jakob Magolan 1 collaboration

Minomi K Subapanditha 1 collaboration

Dillon McKenna 1 collaboration

Chirayu Chokshi 1 collaboration

Neil Savage 1 collaboration

Michelle M Kameda-Smith 1 collaboration

Chitra Venugopal 1 collaboration

Sheila K Singh 1 collaboration

Cigdem Sahin 1 collaboration

Lilia Magomedova 1 collaboration

Thais A M Ferreira 1 collaboration

Jiabao Liu 1 collaboration

Jens Tiefenbach 1 collaboration

Priscilla S Alves 1 collaboration

Fellipe J G Queiroz 1 collaboration

Andressa S de Oliveira 1 collaboration

Mousumi Bhattacharyya 1 collaboration

Julie Grouleff 1 collaboration

Patrícia C N Nogueira 1 collaboration

Edilberto R Silveira 1 collaboration

Daniel C Moreira 1 collaboration

José Roberto Souza de Almeida Leite 1 collaboration

Guilherme D Brand 1 collaboration

Henry Krause 1 collaboration

Carolyn L Cummins 1 collaboration

Luiz A S Romeiro 1 collaboration

Mary M Mader 1 collaboration

Joachim Rudolph 1 collaboration

Ingo V Hartung 1 collaboration

Paul Workman 1 collaboration

William Zuercher 1 collaboration

Qiangmin Zhang 1 collaboration

Kunhong Xiao 1 collaboration

José M Paredes 1 collaboration

Tatyana Mamonova 1 collaboration

W Bruce Sneddon 1 collaboration

Hongda Liu 1 collaboration

Dawei Wang 1 collaboration

Sheng Li 1 collaboration

Jennifer C McGarvey 1 collaboration

Frederic Jean-Alphonse 1 collaboration

Angel Orte 1 collaboration

Peter A Friedman 1 collaboration

Yannis Kalaidzidis 1 collaboration

Leanne E Wybenga-Groot 1 collaboration

Konstantin Weiss 1 collaboration

Nika Vučković 1 collaboration

Adriana Vučetić 1 collaboration

Nhu-An Pham 1 collaboration

Jin H Park 1 collaboration

Alessandro Datti 1 collaboration

Jenny Wang 1 collaboration

Yuhui Wang 1 collaboration

Michael F Moran 1 collaboration

Frances A Shepherd 1 collaboration

Anna Akhmanova 1 collaboration

Marino Zerial 1 collaboration

Ganna Posternak 1 collaboration

Xiaojing Tang 1 collaboration

Pierre Maisonneuve 1 collaboration

Ting Jin 1 collaboration

Hugo Lavoie 1 collaboration

Salima Daou 1 collaboration

Stephen Orlicky 1 collaboration

Theo Goullet de Rugy 1 collaboration

Lauren Caldwell 1 collaboration

Kin Chan 1 collaboration

Pavel Mader 1 collaboration

Cassandra Wong 1 collaboration

Stefan Maier 1 collaboration

Julia Kitaygorodsky 1 collaboration

Brett Larsen 1 collaboration

Karen Colwill 1 collaboration

Zhe Yin 1 collaboration

Derek F Ceccarelli 1 collaboration

Robert A Batey 1 collaboration

Mikko Taipale 1 collaboration

Igor Kurinov 1 collaboration

Jeff Wrana 1 collaboration

Daniel Durocher 1 collaboration

Anne-Claude Gingras 1 collaboration

Marc Therrien 1 collaboration

Frank Sicheri 1 collaboration

David Smil 1 collaboration

Jong Fu Wong 1 collaboration

Eleanor P Williams 1 collaboration

Roslin J Adamson 1 collaboration

Alison Howarth 1 collaboration

David A McLeod 1 collaboration

Soyoung Kim 1 collaboration

Brian J Wilson 1 collaboration

Julie Owen 1 collaboration

Kurumi Y Horiuchi 1 collaboration

Ekaterina Kuznetsova 1 collaboration

Haiching Ma 1 collaboration

J Nicole Hamblin 1 collaboration

Sue Cramp 1 collaboration

Owen G Roberts 1 collaboration

Aled M Edwards 1 collaboration

Alex N Bullock 1 collaboration

Jeff A O'Meara 1 collaboration

Methvin B Isaac 1 collaboration

Maria I Edilova 1 collaboration

Jaclyn C Law 1 collaboration

Safoura Zangiabadi 1 collaboration

Kenneth Ting 1 collaboration

Achire N Mbanwi 1 collaboration

Andrea Arruda 1 collaboration

Mark D Minden 1 collaboration

Ali A Abdul-Sater 1 collaboration

Tania H Watts 1 collaboration

Justin P Pogmore 1 collaboration