Stephen Orlicky

Affiliations

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada.

Publications (9)

Bipartite binding of the N terminus of Skp2 to cyclin A.

Structure (London, England : 1993)

Avec: Susan Kelso , Stephen Orlicky , Jonah Beenstock , Derek F Ceccarelli , Igor Kurinov , Gerald Gish , Frank Sicheri

Engineered Antigen-Binding Fragments for Enhanced Crystallization of Antibody:Antigen Complexes.

Protein science : a publication of the Protein Society

Avec: Heather A Bruce , Alexander U Singer , Ekaterina V Filippova , Levi L Blazer , Jarrett J Adams , Leonie Enderle , Moshe Ben-David , Elizabeth H Radley , Daniel Y L Mao , Victor Pau , Stephen Orlicky , Frank Sicheri , Igor Kourinov , Shane Atwell , Anthony A Kossiakoff , Sachdev S Sidhu

FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation.

Nature communications

Avec: Philip Barbulescu , Chetan K Chana , Matthew K Wong , Ines Ben Makhlouf , Jeffrey P Bruce , Yuqing Feng , Alexander F A Keszei , Cassandra Wong , Rukshana Mohamad-Ramshan , Laura C McGary , Mohammad A Kashem , Derek F Ceccarelli , Stephen Orlicky , Yifei Fang , Huihui Kuang , Mohammad Mazhab-Jafari , Rossanna C Pezo , Ashok S Bhagwat , Trevor J Pugh , Anne-Claude Gingras , Frank Sicheri , Alberto Martin

Functional characterization of a PROTAC directed against BRAF mutant V600E.

Nature chemical biology

Avec: Ganna Posternak , Xiaojing Tang , Pierre Maisonneuve , Ting Jin , Hugo Lavoie , Salima Daou , Stephen Orlicky , Theo Goullet de Rugy , Lauren Caldwell , Kin Chan , Ahmed Aman , Michael Prakesch , Gennady Poda , Pavel Mader , Cassandra Wong , Stefan Maier , Julia Kitaygorodsky , Brett Larsen , Karen Colwill , Zhe Yin , Derek F Ceccarelli , Robert A Batey , Mikko Taipale , Igor Kurinov , David Uehling , Jeff Wrana , Daniel Durocher , Anne-Claude Gingras , Rima Al-Awar , Marc Therrien , Frank Sicheri

SCF

EMBO reports

Avec: Siobhan O'Brien , Susan Kelso , Zachary Steinhart , Stephen Orlicky , Monika Mis , Yunhye Kim , Sichun Lin , Frank Sicheri , Stephane Angers

Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.

Journal of medicinal chemistry

Avec: Janek Szychowski , Robert Papp , Evelyne Dietrich , Bingcan Liu , Frédéric Vallée , Marie-Eve Leclaire , Jimmy Fourtounis , Giovanni Martino , Alexander L Perryman , Victor Pau , Shou Yun Yin , Pavel Mader , Anne Roulston , Jean-Francois Truchon , C Gary Marshall , Mohamed Diallo , Nicole M Duffy , Rino Stocco , Claude Godbout , Alexanne Bonneau-Fortin , Rosie Kryczka , Vivek Bhaskaran , Daniel Mao , Stephen Orlicky , Patrick Beaulieu , Pascal Turcotte , Igor Kurinov , Frank Sicheri , Yael Mamane , Michel Gallant , W Cameron Black

Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry.

Nature communications

Avec: N Tavernier , Y Thomas , S Vigneron , P Maisonneuve , S Orlicky , P Mader , S G Regmi , L Van Hove , N M Levinson , G Gasmi-Seabrook , N Joly , M Poteau , G Velez-Aguilera , O Gavet , A Castro , M Dasso , T Lorca , F Sicheri , L Pintard

A substrate binding model for the KEOPS tRNA modifying complex.

Nature communications

Avec: Jonah Beenstock , Samara Mishelle Ona , Jennifer Porat , Stephen Orlicky , Leo C K Wan , Derek F Ceccarelli , Pierre Maisonneuve , Rachel K Szilard , Zhe Yin , Dheva Setiaputra , Daniel Y L Mao , Morgan Khan , Shaunak Raval , David C Schriemer , Mark A Bayfield , Daniel Durocher , Frank Sicheri

Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.

Science advances

Avec: Daniel St-Cyr , Derek F Ceccarelli , Stephen Orlicky , Almer M van der Sloot , Xiaojing Tang , Susan Kelso , Susan Moore , Clint James , Ganna Posternak , Jasmin Coulombe-Huntington , Thierry Bertomeu , Anne Marinier , Frank Sicheri , Mike Tyers

Réseau de co-auteurs

Frank Sicheri 8 collaborations

Derek F Ceccarelli 5 collaborations

Susan Kelso 3 collaborations

Igor Kurinov 3 collaborations

Jonah Beenstock 2 collaborations

Daniel Y L Mao 2 collaborations

Victor Pau 2 collaborations

Cassandra Wong 2 collaborations

Anne-Claude Gingras 2 collaborations

Ganna Posternak 2 collaborations

Xiaojing Tang 2 collaborations

Pierre Maisonneuve 2 collaborations

Pavel Mader 2 collaborations

Zhe Yin 2 collaborations

Daniel Durocher 2 collaborations

Gerald Gish 1 collaboration

Heather A Bruce 1 collaboration

Alexander U Singer 1 collaboration

Ekaterina V Filippova 1 collaboration

Levi L Blazer 1 collaboration

Jarrett J Adams 1 collaboration

Leonie Enderle 1 collaboration

Moshe Ben-David 1 collaboration

Elizabeth H Radley 1 collaboration

Igor Kourinov 1 collaboration

Shane Atwell 1 collaboration

Anthony A Kossiakoff 1 collaboration

Sachdev S Sidhu 1 collaboration

Philip Barbulescu 1 collaboration

Chetan K Chana 1 collaboration

Matthew K Wong 1 collaboration

Ines Ben Makhlouf 1 collaboration

Jeffrey P Bruce 1 collaboration

Yuqing Feng 1 collaboration

Alexander F A Keszei 1 collaboration

Rukshana Mohamad-Ramshan 1 collaboration

Laura C McGary 1 collaboration

Mohammad A Kashem 1 collaboration

Yifei Fang 1 collaboration

Huihui Kuang 1 collaboration

Mohammad Mazhab-Jafari 1 collaboration

Rossanna C Pezo 1 collaboration

Ashok S Bhagwat 1 collaboration

Trevor J Pugh 1 collaboration

Alberto Martin 1 collaboration

Ting Jin 1 collaboration

Hugo Lavoie 1 collaboration

Salima Daou 1 collaboration

Theo Goullet de Rugy 1 collaboration

Lauren Caldwell 1 collaboration

Kin Chan 1 collaboration

Ahmed Aman 1 collaboration

Michael Prakesch 1 collaboration

Gennady Poda 1 collaboration

Stefan Maier 1 collaboration

Julia Kitaygorodsky 1 collaboration

Brett Larsen 1 collaboration

Karen Colwill 1 collaboration

Robert A Batey 1 collaboration

Mikko Taipale 1 collaboration

David Uehling 1 collaboration

Jeff Wrana 1 collaboration

Rima Al-Awar 1 collaboration

Marc Therrien 1 collaboration

Siobhan O'Brien 1 collaboration

Zachary Steinhart 1 collaboration

Monika Mis 1 collaboration

Yunhye Kim 1 collaboration

Sichun Lin 1 collaboration

Stephane Angers 1 collaboration

Janek Szychowski 1 collaboration

Robert Papp 1 collaboration

Evelyne Dietrich 1 collaboration

Bingcan Liu 1 collaboration

Frédéric Vallée 1 collaboration

Marie-Eve Leclaire 1 collaboration

Jimmy Fourtounis 1 collaboration

Giovanni Martino 1 collaboration

Alexander L Perryman 1 collaboration

Shou Yun Yin 1 collaboration

Anne Roulston 1 collaboration

Jean-Francois Truchon 1 collaboration

C Gary Marshall 1 collaboration

Mohamed Diallo 1 collaboration

Nicole M Duffy 1 collaboration

Rino Stocco 1 collaboration

Claude Godbout 1 collaboration

Alexanne Bonneau-Fortin 1 collaboration

Rosie Kryczka 1 collaboration

Vivek Bhaskaran 1 collaboration

Daniel Mao 1 collaboration

Patrick Beaulieu 1 collaboration

Pascal Turcotte 1 collaboration

Yael Mamane 1 collaboration

Michel Gallant 1 collaboration

W Cameron Black 1 collaboration

N Tavernier 1 collaboration

Y Thomas 1 collaboration

S Vigneron 1 collaboration

P Maisonneuve 1 collaboration

S Orlicky 1 collaboration

P Mader 1 collaboration

S G Regmi 1 collaboration

L Van Hove 1 collaboration

N M Levinson 1 collaboration

G Gasmi-Seabrook 1 collaboration

N Joly 1 collaboration

M Poteau 1 collaboration

G Velez-Aguilera 1 collaboration

O Gavet 1 collaboration

A Castro 1 collaboration

M Dasso 1 collaboration

T Lorca 1 collaboration

F Sicheri 1 collaboration

L Pintard 1 collaboration

Samara Mishelle Ona 1 collaboration

Jennifer Porat 1 collaboration

Leo C K Wan 1 collaboration

Rachel K Szilard 1 collaboration

Dheva Setiaputra 1 collaboration

Morgan Khan 1 collaboration

Shaunak Raval 1 collaboration

David C Schriemer 1 collaboration

Mark A Bayfield 1 collaboration

Daniel St-Cyr 1 collaboration

Almer M van der Sloot 1 collaboration

Susan Moore 1 collaboration

Clint James 1 collaboration

Jasmin Coulombe-Huntington 1 collaboration

Thierry Bertomeu 1 collaboration

Anne Marinier 1 collaboration

Mike Tyers 1 collaboration