A substrate binding model for the KEOPS tRNA modifying complex.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
04 12 2020
Historique:
received: 21 04 2020
accepted: 02 11 2020
entrez: 5 12 2020
pubmed: 6 12 2020
medline: 5 1 2021
Statut: epublish

Résumé

The KEOPS complex, which is conserved across archaea and eukaryotes, is composed of four core subunits; Pcc1, Kae1, Bud32 and Cgi121. KEOPS is crucial for the fitness of all organisms examined. In humans, pathogenic mutations in KEOPS genes lead to Galloway-Mowat syndrome, an autosomal-recessive disease causing childhood lethality. Kae1 catalyzes the universal and essential tRNA modification N

Identifiants

pubmed: 33277478
doi: 10.1038/s41467-020-19990-5
pii: 10.1038/s41467-020-19990-5
pmc: PMC7718258
doi:

Substances chimiques

Archaeal Proteins 0
Multiprotein Complexes 0
RNA, Transfer, Lys 0
RNA, Transfer 9014-25-9

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6233

Subventions

Organisme : CIHR
ID : FDN 143343
Pays : Canada
Organisme : CIHR
ID : FDN 143277
Pays : Canada

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Auteurs

Jonah Beenstock (J)

The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

Samara Mishelle Ona (SM)

The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

Jennifer Porat (J)

Department of Biology, York University, Toronto, ON, Canada.

Stephen Orlicky (S)

The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

Leo C K Wan (LCK)

The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

Derek F Ceccarelli (DF)

The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

Pierre Maisonneuve (P)

The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

Rachel K Szilard (RK)

The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

Zhe Yin (Z)

The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Department of Biochemistry, University of Toronto, Toronto, ON, Canada.

Dheva Setiaputra (D)

The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

Daniel Y L Mao (DYL)

The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

Morgan Khan (M)

Department of Chemistry, University of Calgary, Calgary, AB, Canada.

Shaunak Raval (S)

Department of Chemistry, University of Calgary, Calgary, AB, Canada.

David C Schriemer (DC)

Department of Chemistry, University of Calgary, Calgary, AB, Canada.
Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada.

Mark A Bayfield (MA)

Department of Biology, York University, Toronto, ON, Canada.

Daniel Durocher (D)

The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

Frank Sicheri (F)

The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. sicheri@lunenfeld.ca.
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. sicheri@lunenfeld.ca.
Department of Biochemistry, University of Toronto, Toronto, ON, Canada. sicheri@lunenfeld.ca.

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Classifications MeSH