Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
11 08 2022
11 08 2022
Historique:
pubmed:
27
7
2022
medline:
13
8
2022
entrez:
26
7
2022
Statut:
ppublish
Résumé
PKMYT1 is a regulator of CDK1 phosphorylation and is a compelling therapeutic target for the treatment of certain types of DNA damage response cancers due to its established synthetic lethal relationship with
Identifiants
pubmed: 35880755
doi: 10.1021/acs.jmedchem.2c00552
pmc: PMC9837800
mid: NIHMS1859502
doi:
Substances chimiques
Membrane Proteins
0
Protein Kinase Inhibitors
0
Protein-Tyrosine Kinases
EC 2.7.10.1
PKMYT1 protein, human
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
10251-10284Subventions
Organisme : NIGMS NIH HHS
ID : P30 GM124165
Pays : United States
Organisme : CIHR
Pays : Canada
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