Can glucose-lowering medications improve outcomes in non-diabetic heart failure patients? A Bayesian network meta-analysis.

Glucagon-like peptide 1 receptor agonists Heart failure Metformin Sodium-glucose cotransporter 2 inhibitors

Journal

ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191

Informations de publication

Date de publication:
04 2022
Historique:
revised: 11 01 2022
received: 07 10 2021
accepted: 16 01 2022
pubmed: 30 1 2022
medline: 26 3 2022
entrez: 29 1 2022
Statut: ppublish

Résumé

The cardioprotective effects of glucose-lowering medications in diabetic patients with heart failure (HF) are well known. Several large randomized controlled trials (RCTs) have recently suggested that the cardioprotective effects of glucose-lowering medications extend to HF patients regardless of diabetic status. The aim of this study was to conduct a Bayesian network meta-analysis to evaluate the impact of various glucose-lowering medications on the outcomes of non-diabetic HF patients. Medline and Embase were searched for RCTs investigating the use of glucose-lowering medications in non-diabetic HF patients in August 2021. Studies were included in accordance with the inclusion and exclusion criteria, and data were extracted with a pre-defined datasheet. Primary outcomes include serum N-terminal prohormone of brain natriuretic peptide (NT-proBNP) levels, left ventricular ejection fraction (LVEF), and maximal oxygen consumption (PVO This Bayesian network meta-analysis demonstrated that SGLT2i, when compared with GLP1-RA and metformin, was superior in improving LVEF in HF with reduced ejection fraction patients, as well as improving PVO

Identifiants

pubmed: 35092176
doi: 10.1002/ehf2.13822
pmc: PMC8934935
doi:

Substances chimiques

Glucose IY9XDZ35W2
Sodium-Glucose Transporter 2 Inhibitors 0

Types de publication

Journal Article Meta-Analysis

Langues

eng

Sous-ensembles de citation

IM

Pagination

1338-1350

Informations de copyright

© 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

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Auteurs

Trevor Yeong (T)

Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore.

Aaron Shengting Mai (AS)

Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore.

Oliver Z H Lim (OZH)

Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore.

Cheng Han Ng (CH)

Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore.

Yip Han Chin (YH)

Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore.

Phoebe Tay (P)

Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore.

Chaoxing Lin (C)

Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore.

Mark Muthiah (M)

Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore.
Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore.

Chin Meng Khoo (CM)

Division of Endocrinology, Department of Medicine, National University Hospital, Singapore.

Mayank Dalakoti (M)

Department of Cardiology, National University Heart Centre, Tower Block Level 9, 1E Kent Ridge Road, 119228, Singapore.

Poay-Huan Loh (PH)

Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore.
Department of Cardiology, National University Heart Centre, Tower Block Level 9, 1E Kent Ridge Road, 119228, Singapore.

Mark Chan (M)

Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore.
Department of Cardiology, National University Heart Centre, Tower Block Level 9, 1E Kent Ridge Road, 119228, Singapore.

Tiong-Cheng Yeo (TC)

Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore.
Department of Cardiology, National University Heart Centre, Tower Block Level 9, 1E Kent Ridge Road, 119228, Singapore.

Roger Foo (R)

Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore.
Department of Cardiology, National University Heart Centre, Tower Block Level 9, 1E Kent Ridge Road, 119228, Singapore.

Raymond Wong (R)

Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore.
Department of Cardiology, National University Heart Centre, Tower Block Level 9, 1E Kent Ridge Road, 119228, Singapore.

Nicholas W S Chew (NWS)

Department of Cardiology, National University Heart Centre, Tower Block Level 9, 1E Kent Ridge Road, 119228, Singapore.

Weiqin Lin (W)

Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore.
Department of Cardiology, National University Heart Centre, Tower Block Level 9, 1E Kent Ridge Road, 119228, Singapore.

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