Secretory Production of Tocotrienols in

Batch Cell Culture Techniques Fermentation Metabolic Engineering Saccharomyces cerevisiae / genetics Tocotrienols / metabolism
PDR transporters biosynthesis in situ extraction secretory production vitamin E

Journal

ACS synthetic biology
ISSN: 2161-5063
Titre abrégé: ACS Synth Biol
Pays: United States
ID NLM: 101575075

Informations de publication

Date de publication:
18 02 2022
Historique:
pubmed: 1 2 2022
medline: 1 4 2022
entrez: 31 1 2022
Statut: ppublish

Résumé

Tocotrienols as important components of vitamin E have attracted increasing attention, with recent progress made in their heterologous biosynthesis, but all as intracellular products. Aiming to further improve the tocotrienol production capacity of engineered yeast and to advance toward industrial fermentation of tocotrienols, we first optimized the synthetic pathway to enhance the tocotrienol yield and then attempted to realize their secretory production by exploring biphasic extractive fermentation conditions and screening for endogenous transporters. Finally, a

Identifiants

DOI: 10.1021/acssynbio.1c00484 PMID: 35100508
pubmed: 35100508
doi: 10.1021/acssynbio.1c00484
doi:

Substances chimiques

Tocotrienols 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

788-799

Auteurs

Xue Jiao (X)

Institute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

Bin Shen (B)

Institute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

Min Li (M)

Institute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

Lidan Ye (L)

Institute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
Zhejiang University-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou 311200, China.
ORCID: 0000-0002-6248-8457

Hongwei Yu (H)

Institute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
ORCID: 0000-0002-9144-4496

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Techniques de culture cellulaire en batch › Secretory Production of Tocotrienols in
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Fermentation › Secretory Production of Tocotrienols in
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Génie métabolique › Secretory Production of Tocotrienols in
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Secretory Production of Tocotrienols in
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Vitamine E › Tocotriénols › Secretory Production of Tocotrienols in