Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies.

Animals Cytochrome P-450 Enzyme System / metabolism Diclofenac / metabolism Glucuronosyltransferase / metabolism Hepatocytes / metabolism Lab-On-A-Chip Devices Liver Metabolic Clearance Rate / physiology Models, Biological

Journal

Lab on a chip
ISSN: 1473-0189
Titre abrégé: Lab Chip
Pays: England
ID NLM: 101128948

Informations de publication

Date de publication:
15 03 2022
Historique:
pubmed: 3 2 2022
medline: 19 4 2022
entrez: 2 2 2022
Statut: epublish

Résumé

Microphysiological systems (MPS) are complex and more physiologically realistic cellular

Identifiants

DOI: 10.1039/d1lc01161h PMID: 35107462
pubmed: 35107462
doi: 10.1039/d1lc01161h
doi:

Substances chimiques

Diclofenac 144O8QL0L1
Cytochrome P-450 Enzyme System 9035-51-2
Glucuronosyltransferase EC 2.4.1.17

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1187-1205

Auteurs

Luca Docci (L)

Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland. stephen.fowler@roche.com.
Clinical Pharmacology & Toxicology, University Hospital, Schanzenstrasse 55, 4031, Basel, Switzerland.

Nicolò Milani (N)

Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland. stephen.fowler@roche.com.
Centre for Applied Pharmacokinetic Research, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK.
ORCID: 0000-0002-7477-3140

Thomas Ramp (T)

Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland. stephen.fowler@roche.com.
ORCID: 0000-0003-1145-8423

Andrea A Romeo (AA)

Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland. stephen.fowler@roche.com.
ORCID: 0000-0002-1579-2480

Patricio Godoy (P)

Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland. stephen.fowler@roche.com.

Daniela Ortiz Franyuti (DO)

Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland. stephen.fowler@roche.com.
ORCID: 0000-0002-8783-1960

Stephan Krähenbühl (S)

Clinical Pharmacology & Toxicology, University Hospital, Schanzenstrasse 55, 4031, Basel, Switzerland.

Michael Gertz (M)

Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland. stephen.fowler@roche.com.

Aleksandra Galetin (A)

Centre for Applied Pharmacokinetic Research, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK.
ORCID: 0000-0002-3933-5217

Neil Parrott (N)

Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland. stephen.fowler@roche.com.

Stephen Fowler (S)

Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland. stephen.fowler@roche.com.
ORCID: 0000-0001-7331-3559

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Exploration and application of a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Exploration and application of a...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Phénylacétates › Diclofenac › Exploration and application of a...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Hexosyltransferases › Glucuronosyltransferase › Exploration and application of a...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Exploration and application of a...
questionsmedicales.fr › Équipement et fournitures › Équipement et fournitures électriques › Laboratoires sur puces › Exploration and application of a...
questionsmedicales.fr › Système digestif › Foie › Exploration and application of a...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Taux de clairance métabolique › Exploration and application of a...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Exploration and application of a...