Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators.

Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins / metabolism Embryonic Development High-Throughput Screening Assays Signal Transduction Transforming Growth Factor beta

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
10 03 2022
Historique:
pubmed: 3 2 2022
medline: 7 5 2022
entrez: 2 2 2022
Statut: ppublish

Résumé

We report on the feasibility to harness embryonic development

Identifiants

DOI: 10.1021/acs.jmedchem.1c01800 PMID: 35108017
pubmed: 35108017
doi: 10.1021/acs.jmedchem.1c01800
doi:

Substances chimiques

Bone Morphogenetic Protein 2 0
Bone Morphogenetic Proteins 0
Transforming Growth Factor beta 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3978-3990

Auteurs

Fabian Wesseler (F)

Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.
Compound Management and Screening Center, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.
Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Christian-Albrechts-University of Kiel, Gutenbergstrasse 76, 24118 Kiel, Germany.

Daniel Riege (D)

Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Christian-Albrechts-University of Kiel, Gutenbergstrasse 76, 24118 Kiel, Germany.

Mahesh Puthanveedu (M)

Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.
Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

Jonas Halver (J)

Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.

Eva Müller (E)

Department of Orthopedic Surgery, Otto-von-Guericke University, 39120 Magdeburg, Germany.

Jessica Bertrand (J)

Department of Orthopedic Surgery, Otto-von-Guericke University, 39120 Magdeburg, Germany.

Andrey P Antonchick (AP)

Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.
Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.
Department of Chemistry and Forensics, College of Science and Technology, Nottingham Trent University, Clifton Lane, NG11 8NS Nottingham, United Kingdom.
ORCID: 0000-0003-0435-9443

Sonja Sievers (S)

Compound Management and Screening Center, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.
Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

Herbert Waldmann (H)

Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.
Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.
ORCID: 0000-0002-9606-7247

Dennis Schade (D)

Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Christian-Albrechts-University of Kiel, Gutenbergstrasse 76, 24118 Kiel, Germany.
Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.
Partner Site Kiel, DZHK, German Center for Cardiovascular Research, 24105 Kiel, Germany.
ORCID: 0000-0002-5515-1821

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Protéines morphogénétiques osseuses › Protéine morphogénétique osseuse de type 2 › Probing Embryonic Development Enables the...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Protéines morphogénétiques osseuses › Probing Embryonic Development Enables the...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Probing Embryonic Development Enables the...
questionsmedicales.fr › Techniques d'investigation › Tests de criblage à haut débit › Probing Embryonic Development Enables the...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Probing Embryonic Development Enables the...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Probing Embryonic Development Enables the...