Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
04 02 2022
04 02 2022
Historique:
entrez:
2
2
2022
pubmed:
3
2
2022
medline:
20
4
2022
Statut:
ppublish
Résumé
The mechanisms that drive leukocyte recruitment to the kidney are incompletely understood. Dipeptidase-1 (DPEP1) is a major neutrophil adhesion receptor highly expressed on proximal tubular cells and peritubular capillaries of the kidney. Renal ischemia reperfusion injury (IRI) induces robust neutrophil and monocyte recruitment and causes acute kidney injury (AKI). Renal inflammation and the AKI phenotype were attenuated in
Identifiants
pubmed: 35108057
doi: 10.1126/sciadv.abm0142
pmc: PMC8809686
doi:
Substances chimiques
GPI-Linked Proteins
0
Dipeptidases
EC 3.4.13.-
dipeptidase
EC 3.4.13.18
dipeptidase 1
EC 3.4.13.19
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabm0142Références
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