PlexinD1 Deficiency in Lung Interstitial Macrophages Exacerbates House Dust Mite-Induced Allergic Asthma.
Actins
/ genetics
Airway Resistance
/ immunology
Animals
Asthma
/ immunology
Dermatophagoides pteronyssinus
/ immunology
Disease Models, Animal
Female
Goblet Cells
/ immunology
Immunoglobulin E
/ immunology
Interleukin-10
/ genetics
Intracellular Signaling Peptides and Proteins
/ deficiency
Leukocyte Count
Leukocytes
/ immunology
Lung
/ immunology
Macrophages
/ immunology
Membrane Glycoproteins
/ deficiency
Mice
Mice, Knockout
Mucin 5AC
/ genetics
Mucin-5B
/ genetics
RNA, Messenger
/ genetics
Semaphorins
/ genetics
Th17 Cells
/ immunology
Th2 Cells
/ immunology
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 03 2022
01 03 2022
Historique:
received:
28
01
2021
accepted:
17
12
2021
pubmed:
4
2
2022
medline:
8
3
2022
entrez:
3
2
2022
Statut:
ppublish
Résumé
Interstitial macrophages (IMs) are key regulators of allergic inflammation. We previously showed that the absence of semaphorin 3E (Sema3E) exacerbates asthma features in both acute and chronic asthma models. However, it has not been studied whether Sema3E, via its receptor plexinD1, regulates IM function in allergic asthma. Therefore, we investigated the role of plexinD1 deficiency on IMs in allergic asthma. We found that the absence of plexinD1 in IMs increased airway hyperresponsiveness, airway leukocyte numbers, allergen-specific IgE, goblet cell hyperplasia, and Th2/Th17 cytokine response in the house dust mite (HDM)-induced allergic asthma model.
Identifiants
pubmed: 35110420
pii: jimmunol.2100089
doi: 10.4049/jimmunol.2100089
doi:
Substances chimiques
Actins
0
IL10 protein, mouse
0
Intracellular Signaling Peptides and Proteins
0
Membrane Glycoproteins
0
Muc5ac protein, mouse
0
Muc5b protein, mouse
0
Mucin 5AC
0
Mucin-5B
0
Plxnd1 protein, mouse
0
RNA, Messenger
0
Sema3e protein, mouse
0
Semaphorins
0
alpha-smooth muscle actin, mouse
0
Interleukin-10
130068-27-8
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1272-1279Subventions
Organisme : CIHR
ID : PJT 173291
Pays : Canada
Informations de copyright
Copyright © 2022 by The American Association of Immunologists, Inc.