Loss of

Animals B7-H1 Antigen Carcinoma, Non-Small-Cell Lung / drug therapy Humans Immune Checkpoint Inhibitors / pharmacology Lung Neoplasms / drug therapy Mice Tuberous Sclerosis / drug therapy Tuberous Sclerosis Complex 1 Protein / metabolism Tuberous Sclerosis Complex 2 Protein / metabolism Tumor Microenvironment / genetics

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
04 02 2022
Historique:
entrez: 4 2 2022
pubmed: 5 2 2022
medline: 20 4 2022
Statut: ppublish

Résumé

Tuberous sclerosis complex subunit 1 (

Identifiants

DOI: 10.1126/sciadv.abi9533 PMID: 35119931 PMC: PMC8816329
pubmed: 35119931
doi: 10.1126/sciadv.abi9533
pmc: PMC8816329
doi:

Substances chimiques

B7-H1 Antigen 0
Immune Checkpoint Inhibitors 0
TSC1 protein, human 0
TSC2 protein, human 0
Tsc2 protein, mouse 0
Tuberous Sclerosis Complex 1 Protein 0
Tuberous Sclerosis Complex 2 Protein 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabi9533

Subventions

Organisme : NCI NIH HHS
ID : P50 CA101942
Pays : United States

Références

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pubmed: 29246442
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Auteurs

Qingyuan Huang (Q)

Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China.
Institute of Thoracic Oncology, Fudan University, Shanghai, China.
ORCID: 0000-0003-4389-6188

Fei Li (F)

Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Hai Hu (H)

Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.
ORCID: 0000-0002-6985-8959

Zhaoyuan Fang (Z)

State Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

Zhendong Gao (Z)

Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China.
Institute of Thoracic Oncology, Fudan University, Shanghai, China.

Guozhan Xia (G)

Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China.
Institute of Thoracic Oncology, Fudan University, Shanghai, China.
ORCID: 0000-0003-4632-0512

Wai-Lung Ng (WL)

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China.
ORCID: 0000-0003-2892-6318

Alireza Khodadadi-Jamayran (A)

Applied Bioinformatics Laboratories and Genome Technology Center, Division of Advanced Research Technologies, New York University Langone Medical Center, New York, NY, USA.
ORCID: 0000-0003-2495-7504

Ting Chen (T)

Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.
ORCID: 0000-0003-1725-7956

Jiehui Deng (J)

Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.
ORCID: 0000-0001-7986-8643

Hua Zhang (H)

Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.

Christina Almonte (C)

Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.

Kristen Labbe (K)

Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.
ORCID: 0000-0001-6731-5849

Han Han (H)

Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.

Ke Geng (K)

Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.

Sittinon Tang (S)

Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.

Gordon J Freeman (GJ)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-7210-5616

Yuan Li (Y)

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
ORCID: 0000-0001-5651-819X

Haiquan Chen (H)

Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China.
Institute of Thoracic Oncology, Fudan University, Shanghai, China.
ORCID: 0000-0001-7846-257X

Kwok-Kin Wong (KK)

Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.
ORCID: 0000-0001-6323-235X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Loss of
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD274 › Loss of
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Loss of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Loss of
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques immunologiques › Inhibiteurs de points de contrôle immunitaires › Loss of
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Loss of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Loss of
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Syndromes néoplasiques héréditaires › Complexe de la sclérose tubéreuse › Loss of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Protéine-1 du complexe de la sclérose tubéreuse › Loss of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Protéine-2 du complexe de la sclérose tubéreuse › Loss of
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Loss of