ecDNAs personify cancer gangsters.

Carcinogenesis / genetics Humans Neoplasms / genetics Oncogenes

Journal

Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571

Informations de publication

Date de publication:
03 02 2022
Historique:
entrez: 5 2 2022
pubmed: 6 2 2022
medline: 24 2 2022
Statut: ppublish

Résumé

Alterations to gene regulatory plexuses typify oncogenesis, and two recent studies from Hung, Yost, Xie et al. (Hung et al., 2021) and Yi et al. (2021) collectively reveal the competitive advantage of extrachromosomal DNAs (ecDNAs) to set their own rules to control transcription by clustering into ecDNA hubs through intermolecular interactions that forge hub-specific regulatory plexuses driving high-oncogene expression.

Identifiants

DOI: 10.1016/j.molcel.2022.01.003 PMID: 35120647
pubmed: 35120647
pii: S1097-2765(22)00003-X
doi: 10.1016/j.molcel.2022.01.003
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

500-502

Subventions

Organisme : CIHR
ID : FRN-136963
Pays : Canada
Organisme : CIHR
ID : 153234
Pays : Canada
Organisme : CIHR
ID : 168933
Pays : Canada

Commentaires et corrections

Type : CommentOn
Type : CommentOn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Tina Keshavarzian (T)

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

Mathieu Lupien (M)

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Ontario Institute for Cancer Research, Toronto, Ontario, Canada. Electronic address: mlupien@uhnresearch.ca.

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › ecDNAs personify cancer gangsters.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ecDNAs personify cancer gangsters.
questionsmedicales.fr › Tumeurs › ecDNAs personify cancer gangsters.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes tumoraux › Oncogènes › ecDNAs personify cancer gangsters.