Photoswitchable Pseudoirreversible Butyrylcholinesterase Inhibitors Allow Optical Control of Inhibition
Alzheimer Disease
/ chemically induced
Amyloid beta-Peptides
Animals
Azo Compounds
/ chemical synthesis
Butyrylcholinesterase
/ metabolism
Carbamates
/ chemical synthesis
Cholinesterase Inhibitors
/ chemical synthesis
Cognition
/ drug effects
Kinetics
Mice
Molecular Docking Simulation
Neuroprotective Agents
/ chemical synthesis
Nootropic Agents
/ chemical synthesis
Peptide Fragments
Protein Binding
Stereoisomerism
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
23 02 2022
23 02 2022
Historique:
pubmed:
10
2
2022
medline:
17
3
2022
entrez:
9
2
2022
Statut:
ppublish
Résumé
To develop tools to investigate the biological functions of butyrylcholinesterase (BChE) and the mechanisms by which BChE affects Alzheimer's disease (AD), we synthesized several selective, nanomolar active, pseudoirreversible photoswitchable BChE inhibitors. The compounds were able to specifically influence different kinetic parameters of the inhibition process by light. For one compound, a 10-fold difference in the IC
Identifiants
pubmed: 35138833
doi: 10.1021/jacs.1c13492
doi:
Substances chimiques
Amyloid beta-Peptides
0
Azo Compounds
0
Carbamates
0
Cholinesterase Inhibitors
0
Neuroprotective Agents
0
Nootropic Agents
0
Peptide Fragments
0
amyloid beta-protein (25-35)
0
Butyrylcholinesterase
EC 3.1.1.8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM