Targeting an alternate Wilms' tumor antigen 1 peptide bypasses immunoproteasome dependency.


Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
09 02 2022
Historique:
entrez: 9 2 2022
pubmed: 10 2 2022
medline: 12 4 2022
Statut: ppublish

Résumé

Designing effective antileukemic immunotherapy will require understanding mechanisms underlying tumor control or resistance. Here, we report a mechanism of escape from immunologic targeting in an acute myeloid leukemia (AML) patient, who relapsed 1 year after immunotherapy with engineered T cells expressing a human leukocyte antigen A*02 (HLA-A2)-restricted T cell receptor (TCR) specific for a Wilms' tumor antigen 1 epitope, WT1

Identifiants

pubmed: 35138909
doi: 10.1126/scitranslmed.abg8070
pmc: PMC8985599
mid: NIHMS1784706
doi:

Substances chimiques

Antigens, Neoplasm 0
Epitopes 0
HLA-A2 Antigen 0
Peptides 0
Receptors, Antigen, T-Cell 0
WT1 Proteins 0
Proteasome Endopeptidase Complex EC 3.4.25.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabg8070

Subventions

Organisme : NCI NIH HHS
ID : K08 CA169485
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA018029
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA080416
Pays : United States

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Auteurs

Miranda C Lahman (MC)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98115, USA.

Thomas M Schmitt (TM)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Kelly G Paulson (KG)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
University of Washington School of Medicine, Seattle, WA 98115, USA.

Nathalie Vigneron (N)

Ludwig Institute for Cancer Research, 1200 Brussels, Belgium.
de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.

Denise Buenrostro (D)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Felecia D Wagener (FD)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Valentin Voillet (V)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Hutchinson Centre Research Institute of South Africa, Cape Town 8001, South Africa.

Lauren Martin (L)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Raphael Gottardo (R)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Jason Bielas (J)

Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98115, USA.
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Julie M McElrath (JM)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
University of Washington School of Medicine, Seattle, WA 98115, USA.
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Derek L Stirewalt (DL)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
University of Washington School of Medicine, Seattle, WA 98115, USA.

Era L Pogosova-Agadjanyan (EL)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Cecilia C Yeung (CC)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98115, USA.
University of Washington School of Medicine, Seattle, WA 98115, USA.

Robert H Pierce (RH)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98115, USA.

Daniel N Egan (DN)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
University of Washington School of Medicine, Seattle, WA 98115, USA.

Merav Bar (M)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
University of Washington School of Medicine, Seattle, WA 98115, USA.

Paul C Hendrie (PC)

University of Washington School of Medicine, Seattle, WA 98115, USA.

Sinéad Kinsella (S)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Aesha Vakil (A)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Jonah Butler (J)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Mary Chaffee (M)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Jonathan Linton (J)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Megan S McAfee (MS)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Daniel S Hunter (DS)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Marie Bleakley (M)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98115, USA.

Anthony Rongvaux (A)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Department of Immunology, University of Washington, Seattle, WA 98115, USA.

Benoit J Van den Eynde (BJ)

de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.
Walloon Excellence in Life Sciences and Biotechnology (WELBIO), 1300 Wavre, Belgium.

Aude G Chapuis (AG)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98115, USA.
University of Washington School of Medicine, Seattle, WA 98115, USA.

Philip D Greenberg (PD)

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
University of Washington School of Medicine, Seattle, WA 98115, USA.
Department of Immunology, University of Washington, Seattle, WA 98115, USA.

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