Intratumoural spatial distribution of S100B + folliculostellate cells is associated with proliferation and expression of FSH and ERα in gonadotroph tumours.
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ analysis
Cell Proliferation
/ physiology
Estrogen Receptor alpha
/ metabolism
Female
Follicle Stimulating Hormone
/ metabolism
Gonadotrophs
/ metabolism
Humans
Male
Middle Aged
Neuroendocrine Tumors
/ metabolism
Pituitary Neoplasms
/ metabolism
S100 Calcium Binding Protein beta Subunit
/ metabolism
Folliculostellate cells
Gonadotroph adenoma
S100B + cells
Tumour heterogeneity
Tumour microenvironment
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
09 02 2022
09 02 2022
Historique:
received:
29
11
2021
accepted:
24
01
2022
entrez:
10
2
2022
pubmed:
11
2
2022
medline:
8
3
2022
Statut:
epublish
Résumé
Folliculostellate cells are S100B-expressing cells with numerous functions in the normal anterior pituitary. These cells have also been identified in pituitary neuroendocrine tumours (PitNETs), where their precise role remains elusive. Here, we aimed to build a refined cartography of S100B-expressing cells to characterise their interpatient and intratumoural spatial distribution, and to start identifying their potential functions in PitNETs. High-throughput histological analysis of S100B-stained tumour sections of 54 PitNETs revealed a significant decrease in S100B + cells in PitNETs compared to the normal anterior pituitary. A Ki67 index ≥ 3, a mitosis count > 2/10 per high power fields, and a proliferative status, were all associated with fewer S100B + cells in gonadotroph tumours. Gonadotroph tumours also showed interpatient and intratumoural heterogeneity in the spatial distribution of S100B + cells. The existence of an intratumoural heterogeneity was further confirmed by the incorporation to our spatial analysis of additional markers: Ki67, FSH, LH, ERα and SSTR2. The tumour areas with fewer S100B + cells displayed a higher percentage of Ki67 + cells, whereas strong positive correlations were observed between S100B + , FSH + , and ERα + cells. Such spatial associations suggest that S100B + folliculostellate cells could play a role in gonadotroph tumorigenesis, and may contribute to the maintenance of tumour cells in a low proliferating, FSH + /ERα + differentiated state. Albeit, further in-depth functional studies are required to decipher the mechanisms underlying these spatial associations and to potentially identify a therapeutic use.
Identifiants
pubmed: 35139928
doi: 10.1186/s40478-022-01321-y
pii: 10.1186/s40478-022-01321-y
pmc: PMC8827287
doi:
Substances chimiques
Biomarkers, Tumor
0
ESR1 protein, human
0
Estrogen Receptor alpha
0
S100 Calcium Binding Protein beta Subunit
0
S100B protein, human
0
Follicle Stimulating Hormone
9002-68-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18Informations de copyright
© 2022. The Author(s).
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