questionsmedicales.fr
Cellules
Cellules épithéliales
Cellules gonadotropes
Cellules gonadotropes : Questions médicales fréquentes
Diagnostic
5
Dysfonction hormonale
Hormones gonadotropes
Dosage hormonal
Estradiol
Irrégularités menstruelles
Fertilité
IRM
Tumeurs hypophysaires
Test de stimulation
Fonction hypophysaire
Symptômes
5
Cycles menstruels
Troubles de la libido
Différences sexuelles
Hormones
Troubles endocriniens
Gynécologie
Prévention
5
Prévention
Mode de vie sain
Bilan hormonal
Détection précoce
Alimentation
Santé hormonale
Stress
Équilibre hormonal
Traitements
5
Thérapie hormonale
Chirurgie
Traitement hormonal
Besoins hormonaux
Effets secondaires
Médicaments
Complications
5
Infertilité
Déséquilibres hormonaux
Tumeurs
Complications neurologiques
Grossesse
Fausses couches
Facteurs de risque
5
Âge
Antécédents familiaux
Maladies chroniques
Diabète
Traitements hormonaux
Fonction gonadotrope
Environnement
Perturbateurs endocriniens
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Cellules gonadotropes : Questions médicales les plus fréquentes",
"headline": "Cellules gonadotropes : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Cellules gonadotropes : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-01-08",
"dateModified": "2026-03-28",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Cellules gonadotropes"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Cellules épithéliales",
"url": "https://questionsmedicales.fr/mesh/D004847",
"about": {
"@type": "MedicalCondition",
"name": "Cellules épithéliales",
"code": {
"@type": "MedicalCode",
"code": "D004847",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "A11.436"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Cellules gonadotropes",
"alternateName": "Gonadotrophs",
"code": {
"@type": "MedicalCode",
"code": "D052681",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Hiroya Kadokawa",
"url": "https://questionsmedicales.fr/author/Hiroya%20Kadokawa",
"affiliation": {
"@type": "Organization",
"name": "Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi-shi, Yamaguchi-ken, 1677-1, Japan. hiroya@yamaguchi-u.ac.jp."
}
},
{
"@type": "Person",
"name": "Mirela Diana Ilie",
"url": "https://questionsmedicales.fr/author/Mirela%20Diana%20Ilie",
"affiliation": {
"@type": "Organization",
"name": "Endocrinology Department, \"C. I. Parhon\" National Institute of Endocrinology, Bucharest, Bucharest-Ilfov, Romania."
}
},
{
"@type": "Person",
"name": "Maria Maksymowicz",
"url": "https://questionsmedicales.fr/author/Maria%20Maksymowicz",
"affiliation": {
"@type": "Organization",
"name": "Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland."
}
},
{
"@type": "Person",
"name": "Gérald Raverot",
"url": "https://questionsmedicales.fr/author/G%C3%A9rald%20Raverot",
"affiliation": {
"@type": "Organization",
"name": "Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, \"Groupement Hospitalier Est\" Hospices Civils de Lyon, Bron, Auvergne-Rhône-Alpes, France."
}
},
{
"@type": "Person",
"name": "Stanko S Stojilkovic",
"url": "https://questionsmedicales.fr/author/Stanko%20S%20Stojilkovic",
"affiliation": {
"@type": "Organization",
"name": "Section on Cellular Signaling, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: stojilks@mail.nih.gov."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Treatment Options for Gonadotroph Tumors: Current State and Perspectives.",
"datePublished": "2020-10-01",
"url": "https://questionsmedicales.fr/article/32735647",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1210/clinem/dgaa497"
}
},
{
"@type": "ScholarlyArticle",
"name": "Functional pituitary gonadotroph adenoma in male patients: Case report.",
"datePublished": "2022-Aug-00",
"url": "https://questionsmedicales.fr/article/36280939",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.47391/JPMA.4359"
}
},
{
"@type": "ScholarlyArticle",
"name": "Immune Landscape of Pituitary Tumors Reveals Association Between Macrophages and Gonadotroph Tumor Invasion.",
"datePublished": "2020-11-01",
"url": "https://questionsmedicales.fr/article/32785693",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1210/clinem/dgaa520"
}
},
{
"@type": "ScholarlyArticle",
"name": "[Gonadotroph Pituitary Adenoma Causing Severe Headache Following Repeated Use of GnRH Agonist for Prostate Cancer].",
"datePublished": "2019-May-00",
"url": "https://questionsmedicales.fr/article/31247696",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.14989/ActaUrolJap_65_5_171"
}
},
{
"@type": "ScholarlyArticle",
"name": "Clinical characteristics and outcomes of null-cell versus silent gonadotroph adenomas in a series of 1166 pituitary adenomas from a single institution.",
"datePublished": "2020-06-00",
"url": "https://questionsmedicales.fr/article/32480370",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3171/2020.3.FOCUS20114"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Cellules",
"item": "https://questionsmedicales.fr/mesh/D002477"
},
{
"@type": "ListItem",
"position": 3,
"name": "Cellules épithéliales",
"item": "https://questionsmedicales.fr/mesh/D004847"
},
{
"@type": "ListItem",
"position": 4,
"name": "Cellules gonadotropes",
"item": "https://questionsmedicales.fr/mesh/D052681"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Cellules gonadotropes - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Cellules gonadotropes",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2026-04-28",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Cellules gonadotropes",
"description": "Comment diagnostiquer une dysfonction gonadotrope ?\nQuels tests sont utilisés pour évaluer les gonadotropes ?\nQuels symptômes indiquent un problème avec les gonadotropes ?\nLes imageries sont-elles nécessaires pour le diagnostic ?\nComment évaluer la fonction hypophysaire ?",
"url": "https://questionsmedicales.fr/mesh/D052681#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Cellules gonadotropes",
"description": "Quels sont les symptômes d'une carence en gonadotropes ?\nComment se manifeste un excès de gonadotropes ?\nLes symptômes varient-ils selon le sexe ?\nQuels signes cliniques sont associés aux tumeurs gonadotropes ?\nLes symptômes peuvent-ils être confondus avec d'autres conditions ?",
"url": "https://questionsmedicales.fr/mesh/D052681#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Cellules gonadotropes",
"description": "Peut-on prévenir les troubles gonadotropes ?\nQuels examens réguliers sont recommandés ?\nL'alimentation influence-t-elle la fonction gonadotrope ?\nLe stress a-t-il un impact sur les gonadotropes ?\nLes habitudes de vie peuvent-elles affecter la fertilité ?",
"url": "https://questionsmedicales.fr/mesh/D052681#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Cellules gonadotropes",
"description": "Quels traitements existent pour les troubles gonadotropes ?\nComment les hormones sont-elles administrées ?\nLes traitements sont-ils différents pour les hommes et les femmes ?\nLes médicaments peuvent-ils avoir des effets secondaires ?\nLa chirurgie est-elle toujours nécessaire ?",
"url": "https://questionsmedicales.fr/mesh/D052681#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Cellules gonadotropes",
"description": "Quelles complications peuvent survenir avec des troubles gonadotropes ?\nLes tumeurs gonadotropes peuvent-elles être graves ?\nComment les troubles gonadotropes affectent-ils la grossesse ?\nLes complications sont-elles réversibles ?\nLes troubles gonadotropes augmentent-ils le risque de cancer ?",
"url": "https://questionsmedicales.fr/mesh/D052681#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Cellules gonadotropes",
"description": "Quels sont les facteurs de risque pour les troubles gonadotropes ?\nLe mode de vie influence-t-il les risques ?\nLes maladies chroniques affectent-elles les gonadotropes ?\nLes traitements médicaux peuvent-ils être un facteur de risque ?\nLes facteurs environnementaux jouent-ils un rôle ?",
"url": "https://questionsmedicales.fr/mesh/D052681#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une dysfonction gonadotrope ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un diagnostic se fait par des tests hormonaux et une évaluation clinique."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer les gonadotropes ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les dosages de LH, FSH et estradiol sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent un problème avec les gonadotropes ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des irrégularités menstruelles ou des problèmes de fertilité peuvent indiquer un problème."
}
},
{
"@type": "Question",
"name": "Les imageries sont-elles nécessaires pour le diagnostic ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une IRM peut être nécessaire pour détecter des tumeurs hypophysaires."
}
},
{
"@type": "Question",
"name": "Comment évaluer la fonction hypophysaire ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de stimulation hormonale peuvent évaluer la fonction hypophysaire."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une carence en gonadotropes ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent l'infertilité, l'aménorrhée et la baisse de libido."
}
},
{
"@type": "Question",
"name": "Comment se manifeste un excès de gonadotropes ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un excès peut entraîner des cycles menstruels irréguliers et des troubles de la libido."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon le sexe ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent différer entre hommes et femmes en fonction des hormones."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques sont associés aux tumeurs gonadotropes ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tumeurs peuvent causer des maux de tête, des troubles visuels et des déséquilibres hormonaux."
}
},
{
"@type": "Question",
"name": "Les symptômes peuvent-ils être confondus avec d'autres conditions ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent être similaires à ceux d'autres troubles endocriniens ou gynécologiques."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les troubles gonadotropes ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines conditions peuvent être évitées par un mode de vie sain et un suivi médical."
}
},
{
"@type": "Question",
"name": "Quels examens réguliers sont recommandés ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des bilans hormonaux réguliers peuvent aider à détecter des anomalies précocement."
}
},
{
"@type": "Question",
"name": "L'alimentation influence-t-elle la fonction gonadotrope ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation équilibrée peut soutenir la santé hormonale et reproductive."
}
},
{
"@type": "Question",
"name": "Le stress a-t-il un impact sur les gonadotropes ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress peut perturber l'équilibre hormonal et affecter la fonction gonadotrope."
}
},
{
"@type": "Question",
"name": "Les habitudes de vie peuvent-elles affecter la fertilité ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des habitudes comme le tabagisme ou l'alcool peuvent nuire à la fertilité."
}
},
{
"@type": "Question",
"name": "Quels traitements existent pour les troubles gonadotropes ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des thérapies hormonales et, dans certains cas, la chirurgie."
}
},
{
"@type": "Question",
"name": "Comment les hormones sont-elles administrées ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent être administrées par injection ou par voie orale, selon le cas."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils différents pour les hommes et les femmes ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent varier en fonction des besoins hormonaux spécifiques."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils avoir des effets secondaires ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements hormonaux peuvent entraîner des effets secondaires comme des nausées."
}
},
{
"@type": "Question",
"name": "La chirurgie est-elle toujours nécessaire ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, la chirurgie est réservée aux cas de tumeurs ou d'autres anomalies significatives."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des troubles gonadotropes ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent l'infertilité, des troubles menstruels et des déséquilibres hormonaux."
}
},
{
"@type": "Question",
"name": "Les tumeurs gonadotropes peuvent-elles être graves ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent causer des complications neurologiques et endocriniennes."
}
},
{
"@type": "Question",
"name": "Comment les troubles gonadotropes affectent-ils la grossesse ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent entraîner des complications comme des fausses couches ou des grossesses ectopiques."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement approprié."
}
},
{
"@type": "Question",
"name": "Les troubles gonadotropes augmentent-ils le risque de cancer ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines conditions peuvent augmenter le risque de cancers hormonodépendants."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les troubles gonadotropes ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'âge, les antécédents familiaux et les déséquilibres hormonaux."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il les risques ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des habitudes comme le tabagisme et l'obésité augmentent les risques."
}
},
{
"@type": "Question",
"name": "Les maladies chroniques affectent-elles les gonadotropes ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines maladies chroniques, comme le diabète, peuvent perturber la fonction gonadotrope."
}
},
{
"@type": "Question",
"name": "Les traitements médicaux peuvent-ils être un facteur de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains traitements hormonaux peuvent affecter la fonction gonadotrope."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux jouent-ils un rôle ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des perturbateurs endocriniens peut influencer la santé gonadotrope."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 28/03/2026
Contenu vérifié selon les dernières recommandations médicales
6 publications dans cette catégorie
Affiliations :
Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi-shi, Yamaguchi-ken, 1677-1, Japan. hiroya@yamaguchi-u.ac.jp.
5 publications dans cette catégorie
Affiliations :
Endocrinology Department, "C. I. Parhon" National Institute of Endocrinology, Bucharest, Bucharest-Ilfov, Romania.
Publications dans "Cellules gonadotropes" :
4 publications dans cette catégorie
Affiliations :
Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Publications dans "Cellules gonadotropes" :
3 publications dans cette catégorie
Affiliations :
Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, "Groupement Hospitalier Est" Hospices Civils de Lyon, Bron, Auvergne-Rhône-Alpes, France.
Publications dans "Cellules gonadotropes" :
3 publications dans cette catégorie
Affiliations :
Section on Cellular Signaling, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: stojilks@mail.nih.gov.
Publications dans "Cellules gonadotropes" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Publications dans "Cellules gonadotropes" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Publications dans "Cellules gonadotropes" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Publications dans "Cellules gonadotropes" :
3 publications dans cette catégorie
Affiliations :
Department of Neurosurgery, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Publications dans "Cellules gonadotropes" :
3 publications dans cette catégorie
Affiliations :
Department of Neurosurgery, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Publications dans "Cellules gonadotropes" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Publications dans "Cellules gonadotropes" :
3 publications dans cette catégorie
Affiliations :
Pathology Department, "Groupement Hospitalier Est" Hospices Civils de Lyon, 69677 Bron, France.
Publications dans "Cellules gonadotropes" :
3 publications dans cette catégorie
Affiliations :
Neurosurgery Department, "Groupement Hospitalier Est" Hospices Civils de Lyon, 69677 Bron, France.
Publications dans "Cellules gonadotropes" :
3 publications dans cette catégorie
Affiliations :
Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France.
Publications dans "Cellules gonadotropes" :
3 publications dans cette catégorie
Affiliations :
Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France.
Publications dans "Cellules gonadotropes" :
2 publications dans cette catégorie
Affiliations :
Centre for Research and Development of Bioresources, Osaka Prefecture University, 1-2 Gakuen-cho, Naka-ku, Sakai, 599-8531, Japan.
Publications dans "Cellules gonadotropes" :
2 publications dans cette catégorie
Affiliations :
Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi-shi, Yamaguchi-ken, 1677-1, Japan.
Publications dans "Cellules gonadotropes" :
2 publications dans cette catégorie
Affiliations :
Centre for Research and Development of Bioresources, Osaka Prefecture University, 1-2 Gakuen-cho, Naka-ku, Sakai, 599-8531, Japan.
Publications dans "Cellules gonadotropes" :
2 publications dans cette catégorie
Affiliations :
Department of Obstetrics and Gynecology, The University of Tokyo Hospital, Tokyo 1138655, Japan.
Publications dans "Cellules gonadotropes" :
2 publications dans cette catégorie
Affiliations :
Department of Pituitary and Hypothalamic Surgery, Toranomon Hospital, Tokyo 1058470, Japan.
Publications dans "Cellules gonadotropes" :
Gonadotroph tumors represent approximatively one-third of anterior pituitary tumors, but despite their frequency, no medical treatment is currently recommended for them. This would be greatly needed b...
We performed PubMed searches in March 2020 using the term "gonadotroph" in combination with 36 different keywords related to dopamine type 2 receptor agonists, somatostatin receptor (SST) ligands, tem...
SST2 analogs have demonstrated only very limited antitumor effect, while high-dose cabergoline has been more effective in preventing tumor regrowth, but still in only a minority of cases. In the setti...
Gonadotroph tumors need better phenotyping in terms of both tumor cells and associated tumor microenvironment to improve their treatment. Until formal recommendations will be available, we provide the...
Pituitary gonadotroph adenomas are common but very rarely do they secrete biologically active luteinizing hormone (LH) and follicle-stimulating hormone (FSH). There have been case studies reporting hi...
Pituitary neuroendocrine tumors (PitNETs) are frequent intracranial neoplasms that present heterogenic characteristics. Little is known about the immune cell network that exists in PitNETs and its con...
Here we combined flow cytometry, t-SNE analysis, and histological approaches to define the immune landscape of surgically resected PitNETs. Xenografts of rodent pituitary tumor cells and resected PitN...
We report that gonadotroph PitNETs present an increased CD68+ macrophage signature compared to somatotroph, lactotroph, and corticotroph PitNETs. Transcriptomic and histological characterizations conf...
Gonadotroph tumor drive the recruitment of macrophages and their subsequent polarization to an M2-like phenotype. More importantly, the association between infiltrating CD68+/CD163+ macrophages and th...
Gonadotropin-releasing hormone (GnRH) agonists play an important role in androgen deprivation therapy (ADT) employed for locally advanced prostate cancer. A 76-year-old man presented with elevated lev...
Nonfunctioning pituitary adenomas present without biochemical or clinical signs of hormone excess and are the second most common type of pituitary adenomas. The 2017 WHO classification scheme of pitui...
The records of 1166 patients who underwent transsphenoidal surgery for pituitary adenoma between 2012 and 2019 at a single institution were retrospectively reviewed. Patient demographics and clinical ...
Of the overall pituitary adenoma cohort, 12.8% (n = 149) were SGAs and 9.2% (n = 107) NCAs. NCAs were significantly more common in female patients than SGAs (61.7% vs 26.8%, p < 0.001). There were no ...
This study supports the definition of NCAs and SGAs as separate subgroups of nonfunctioning pituitary adenomas, and it highlights significant differences in long-term clinical outcomes, including tumo...
Since 2017, hormone-negative pituitary neuroendocrine tumors expressing the steroidogenic factor SF1 have been recognized as gonadotroph tumors (GnPT) but have been poorly studied. To further characte...
Gonadotroph pituitary neuroendocrine tumors (PitNETs) can express follicle-stimulating hormone (FSH) and luteinizing hormone (LH) or be hormone negative, but they rarely secrete hormones. During tumor...
To study the effect of EMT on hormone expression in gonadotroph nonfunctioning (NF)-PitNETs....
Molecular and clinical analyses of 105 gonadotroph PitNETs. Immunohistochemical studies and real-time quantitative polymerase chain reaction were performed for FSH, LH, E-cadherin, and ERα. Further an...
All patients were operated on in the same tertiary referral center....
NF-PitNET with high FSH expression had decreased immunohistochemical staining for membranous E-cadherin (P < .0001) and increased staining for nuclear E-cadherin (P < .0001). Furthermore, high FSH exp...
In gonadotroph PitNETs, FSH staining is related to E-cadherin, ERα expression, and circulating levels of P-FSH. There was no association between FSH staining and invasiveness. The clinical significanc...
Some patients develop immunoglobulin G4 (IgG4)-related hypophysitis associated with systemic diseases. More than 30 cases of IgG4-related hypophysitis have been reported. However, biopsy has rarely be...
A 56-year-old Japanese man arrived at the hospital with visual impairment, bitemporal hemianopia, and right abducens nerve palsy. Magnetic resonance imaging revealed pituitary body and stalk swelling ...
This is the first reported case of IgG4-related hypophysitis with PitNET. Although no pathological findings indicating a relationship between the two conditions were found, we were able to preoperativ...
Functioning gonadotroph adenomas (FGAs) are rare pituitary tumours stimulating ovarian function with potential life-threatening consequences in women. However, a lack of aggregated clinical experience...
A retrospective observational study; audit of eight UK regional pituitary centres for cases of FGAs....
Specialist neuroendocrine centres in the United Kingdom....
Women diagnosed with FGA-induced OHSS. Description of their clinical course....
Seven cases of FGA were identified in women, all causing OHSS. Mean age was 33.4 years at diagnosis. Abdominal pain, irregular periods, headache, and visual disturbances were reported at presentation ...
FGA is a rare cause of spontaneous OHSS. TSS improves clinical and biochemical features of ovarian hyperstimulation in FGAs. Improved awareness of FGA will prevent inappropriate emergency ovarian surg...
Functioning gonadotroph adenomas (FGAs) are rare tumors, as the overwhelming majority of gonadotroph tumors are clinically silent. Literature is based on case reports and small case series. Gonadotrop...