Ethanolamine plasmalogens derived from scallops stimulate both follicle-stimulating hormone and luteinizing hormone secretion by bovine gonadotrophs.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
06 10 2022
06 10 2022
Historique:
received:
26
04
2022
accepted:
19
09
2022
entrez:
6
10
2022
pubmed:
7
10
2022
medline:
12
10
2022
Statut:
epublish
Résumé
Brain ethanolamine plasmalogens (EPls) are the only known ligands of G-protein-coupled receptor 61, a novel receptor that stimulates follicle-stimulating hormone (FSH), but not luteinizing hormone (LH), secretion by bovine gonadotrophs. We hypothesized that the recently developed neuroprotective EPls extracted from scallop (Pecten yessoensis) (scallop EPls) could stimulate FSH secretion by gonadotrophs. To test this hypothesis, bovine gonadotrophs were cultured for 3.5 days and treated with increasing concentrations of scallop EPls. FSH secretion was stimulated by all tested concentrations of scallop EPls (P < 0.05). Surprisingly, LH secretion was stimulated by both 0.5 (P < 0.05) and 5 (P < 0.01) ng/mL of scallop EPls. To clarify the important differences between bovine brain and scallop EPls, we utilized two-dimensional liquid chromatography-mass spectrometry, which revealed 44 peaks, including 10 large peaks. Among them, eight were scallop-specific EPl molecular species, occupying approximately 58% of the total area percentage of scallop EPls. Almost all large peaks contained 4, 5, or 6 unsaturated double bonds in the carbon chain at the sn-2 position of the glycerol backbone. Our results showed that EPls from scallops, lacking pituitary glands, stimulated both FSH and LH secretion by bovine gonadotrophs.
Identifiants
pubmed: 36202862
doi: 10.1038/s41598-022-20794-4
pii: 10.1038/s41598-022-20794-4
pmc: PMC9537335
doi:
Substances chimiques
Plasmalogens
0
Receptors, G-Protein-Coupled
0
phosphatidal ethanolamines
0
Gonadotropin-Releasing Hormone
33515-09-2
Carbon
7440-44-0
Follicle Stimulating Hormone
9002-68-0
Glycerol
PDC6A3C0OX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16789Informations de copyright
© 2022. The Author(s).
Références
Domest Anim Endocrinol. 2018 Jul;64:77-83
pubmed: 29754010
Biosci Biotechnol Biochem. 2009 Dec;73(12):2621-5
pubmed: 19966491
Biochim Biophys Acta. 2012 Sep;1822(9):1442-52
pubmed: 22627108
Gen Comp Endocrinol. 2019 Oct 1;282:113201
pubmed: 31199924
Life Sci. 2011 Nov 21;89(21-22):765-72
pubmed: 21971119
Anim Reprod Sci. 2014 Nov 30;150(3-4):84-95
pubmed: 25301533
J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 1;1077-1078:35-43
pubmed: 29413575
Parkinsons Dis. 2020 Feb 19;2020:2671070
pubmed: 32148751
Lipids. 2014 Dec;49(12):1261-73
pubmed: 25385495
Anal Biochem. 2007 Nov 1;370(1):54-9
pubmed: 17599799
J Reprod Dev. 2020 Apr 10;66(2):135-141
pubmed: 31902805
Front Cell Dev Biol. 2021 Jul 21;9:673917
pubmed: 34368127
Can J Biochem Physiol. 1959 Aug;37(8):911-7
pubmed: 13671378
Development. 2017 May 1;144(9):1588-1599
pubmed: 28465334
Biol Reprod. 2000 May;62(5):1109-15
pubmed: 10775155
Evid Based Complement Alternat Med. 2018 Nov 15;2018:3752723
pubmed: 30581481
Mol Reprod Dev. 2007 Jan;74(1):108-15
pubmed: 16941661
Lipids. 1993 Jun;28(6):565-8
pubmed: 8355583
Lipids. 2016 Feb;51(2):199-210
pubmed: 26732602
Anim Reprod Sci. 2022 Jun;241:106992
pubmed: 35580407
Sci Rep. 2021 Feb 26;11(1):4757
pubmed: 33637828
Nat Commun. 2014 Dec 12;5:5719
pubmed: 25502755
Environ Sci Pollut Res Int. 2020 Jan;27(2):1475-1484
pubmed: 31748993
J Biol Chem. 1957 May;226(1):497-509
pubmed: 13428781
Biol Reprod. 2011 Oct;85(4):770-8
pubmed: 21734267
J Anim Sci. 1992 Jun;70(6):1661-6
pubmed: 1634389
Biol Reprod. 2017 Jul 1;97(1):153-161
pubmed: 28859283
Reprod Fertil Dev. 2018 Aug;30(9):1192-1203
pubmed: 29533759
PLoS One. 2016 Mar 02;11(3):e0150846
pubmed: 26934370
J Reprod Dev. 2017 Oct 18;63(5):519-525
pubmed: 28781349
Sci Rep. 2020 Jan 16;10(1):427
pubmed: 31949186
Anim Reprod Sci. 2002 Mar 15;70(1-2):13-21
pubmed: 11841903
Anim Reprod Sci. 2008 Jan 30;103(3-4):360-5
pubmed: 17604578
Behav Res Methods. 2007 May;39(2):175-91
pubmed: 17695343
Front Cell Dev Biol. 2022 Jun 02;10:894734
pubmed: 35721497
J Steroid Biochem Mol Biol. 2020 Nov;204:105756
pubmed: 32979503
J Reprod Dev. 2020 Aug 20;66(4):291-297
pubmed: 32249236
Anim Sci J. 2020 Jan;91(1):e13467
pubmed: 33043536
Front Endocrinol (Lausanne). 2021 Jan 27;11:619352
pubmed: 33584547
Anim Reprod Sci. 2017 Jun;181:93-102
pubmed: 28433506
Biol Reprod. 1979 Oct;21(3):735-47
pubmed: 91391
Domest Anim Endocrinol. 1987 Apr;4(2):123-32
pubmed: 2853664
Adv Exp Med Biol. 2020;1299:195-212
pubmed: 33417216
Anim Reprod Sci. 2010 Sep;121(3-4):267-72
pubmed: 20594780
Front Cell Dev Biol. 2022 Feb 09;10:828282
pubmed: 35223852