Updating the Landscape for Functioning Gonadotroph Tumors.
functioning
gonadotroph pituitary adenoma
ovarian hyperstimulation syndrome
precocious puberty
testicular enlargement
Journal
Medicina (Kaunas, Lithuania)
ISSN: 1648-9144
Titre abrégé: Medicina (Kaunas)
Pays: Switzerland
ID NLM: 9425208
Informations de publication
Date de publication:
08 Aug 2022
08 Aug 2022
Historique:
received:
10
07
2022
revised:
03
08
2022
accepted:
04
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
Functioning gonadotroph adenomas (FGAs) are rare tumors, as the overwhelming majority of gonadotroph tumors are clinically silent. Literature is based on case reports and small case series. Gonadotroph tumors are poorly differentiated and produce and secrete hormones inefficiently, but in exceptional cases, they cause clinical syndromes due to hypersecretion of intact gonadotropins. The clinical spectrum of endocrine dysfunction includes an exaggerated response of ovaries characterized as ovarian hyperstimulation syndrome (OHSS) in premenopausal females and adolescent girls, testicular enlargement in males, and isosexual precocious puberty in children. Transsphenoidal surgery and removal of tumor reduces hormonal hypersecretion, improves endocrine dysfunction, and provides tissue for further analysis. Medical therapies (somatostatin analogues, dopamine agonists, GnRH agonists/antagonists) are partially or totally ineffective in many cases, especially with respect to antitumor effect. This review aims to update recent literature on these rare functioning tumors and highlight their therapeutic management.
Identifiants
pubmed: 36013538
pii: medicina58081071
doi: 10.3390/medicina58081071
pmc: PMC9414558
pii:
doi:
Substances chimiques
Somatostatin
51110-01-1
Follicle Stimulating Hormone
9002-68-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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