A Score to Assess Mortality After Percutaneous Mitral Valve Repair.

Aged Cardiac Catheterization / adverse effects Female Follow-Up Studies Heart Valve Prosthesis Implantation / adverse effects Humans Italy / epidemiology Male Mitral Valve / surgery Mitral Valve Insufficiency / mortality Postoperative Complications / mortality Registries Retrospective Studies Risk Factors Stroke Volume / physiology Time Factors Treatment Outcome

mortality score transcatheter edge-to-edge mitral valve repair

Journal

Journal of the American College of Cardiology

ISSN: 1558-3597

Titre abrégé: J Am Coll Cardiol

Pays: United States

ID NLM: 8301365

Informations de publication

Date de publication:
15 02 2022

Historique:

received: 19 10 2021

revised: 04 11 2021

accepted: 08 11 2021

entrez: 11 2 2022

pubmed: 12 2 2022

medline: 26 2 2022

Statut: ppublish

Résumé

Risk stratification for transcatheter edge-to-edge mitral valve repair (TEER) is paramount in the decision-making process for treating severe mitral regurgitation (MR). This study sought to create and validate a user-friendly score (MitraScore) to predict the risk of mortality in patients undergoing TEER. The derivation cohort was based on a multicentric international registry that included 1,119 patients referred for TEER between 2012 and 2020. Score discrimination was assessed using Harrell's c-statistic, and the calibration was evaluated with the Gronnesby and Borgan goodness-of-fit test. An external validation was carried out in 725 patients from the GIOTTO registry. After multivariate analysis, we identified 8 independent predictors of mortality during the follow-up (2.1 ± 1.8 years): age ≥75 years, anemia, glomerular filtrate rate <60 mL/min/1.73 m The MitraScore is a simple prediction algorithm for the prediction of follow-up mortality in patients treated with TEER.

Sections du résumé

BACKGROUND

Risk stratification for transcatheter edge-to-edge mitral valve repair (TEER) is paramount in the decision-making process for treating severe mitral regurgitation (MR).

OBJECTIVES

This study sought to create and validate a user-friendly score (MitraScore) to predict the risk of mortality in patients undergoing TEER.

METHODS

The derivation cohort was based on a multicentric international registry that included 1,119 patients referred for TEER between 2012 and 2020. Score discrimination was assessed using Harrell's c-statistic, and the calibration was evaluated with the Gronnesby and Borgan goodness-of-fit test. An external validation was carried out in 725 patients from the GIOTTO registry.

RESULTS

After multivariate analysis, we identified 8 independent predictors of mortality during the follow-up (2.1 ± 1.8 years): age ≥75 years, anemia, glomerular filtrate rate <60 mL/min/1.73 m

CONCLUSIONS

The MitraScore is a simple prediction algorithm for the prediction of follow-up mortality in patients treated with TEER.

Identifiants

DOI: 10.1016/j.jacc.2021.11.041 PMID: 35144748

pubmed: 35144748

pii: S0735-1097(21)08316-9

doi: 10.1016/j.jacc.2021.11.041

pii:

doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

Pagination

562-573

Commentaires et corrections

Type : CommentIn