New diarylheptanoid dimers as GLP-1 secretagogues and multiple-enzyme inhibitors from Alpinia katsumadai.

Alpinia / chemistry Diarylheptanoids / chemistry Enzyme Inhibitors / pharmacology Glucagon-Like Peptide 1 Glycoside Hydrolase Inhibitors / pharmacology Hypoglycemic Agents / chemistry Plant Extracts / chemistry Secretagogues alpha-Glucosidases
Alpinia katsumadai Diarylheptanoid dimers Enzyme inhibitors GLP-1 secretagogues Katsumadainols C(1)−C(10) Multiple-target antidiabetic agents

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
03 2022
Historique:
received: 24 11 2021
revised: 06 01 2022
accepted: 31 01 2022
pubmed: 13 2 2022
medline: 14 6 2022
entrez: 12 2 2022
Statut: ppublish

Résumé

Ten new diarylheptanoid dimers, katsumadainols C

Identifiants

DOI: 10.1016/j.bioorg.2022.105653 PMID: 35149263
pubmed: 35149263
pii: S0045-2068(22)00058-X
doi: 10.1016/j.bioorg.2022.105653
pii:
doi:

Substances chimiques

Diarylheptanoids 0
Enzyme Inhibitors 0
Glycoside Hydrolase Inhibitors 0
Hypoglycemic Agents 0
Plant Extracts 0
Secretagogues 0
Glucagon-Like Peptide 1 89750-14-1
alpha-Glucosidases EC 3.2.1.20

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

105653

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Xiao-Feng He (XF)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.

Sheng-Li Wu (SL)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China; School of Life Sciences, Yunnan University, Kunming 650500, People's Republic of China.

Ji-Jun Chen (JJ)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.

Jing Hu (J)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.

Xiao-Yan Huang (XY)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.

Tian-Ze Li (TZ)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.

Xue-Mei Zhang (XM)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.

Yuan-Qiang Guo (YQ)

College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People's Republic of China.

Chang-An Geng (CA)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China. Electronic address: gengchangan@mail.kib.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lilianae › Zingiberales › Zingiberaceae › Alpinia › New diarylheptanoid dimers as GLP-1...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › New diarylheptanoid dimers as GLP-1...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › New diarylheptanoid dimers as GLP-1...
questionsmedicales.fr › Hormones gastrointestinales › Peptides glucagon-like › Glucagon-like peptide 1 › New diarylheptanoid dimers as GLP-1...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs des glycoside hydrolases › New diarylheptanoid dimers as GLP-1...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › New diarylheptanoid dimers as GLP-1...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › New diarylheptanoid dimers as GLP-1...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Sécrétagogues › New diarylheptanoid dimers as GLP-1...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › alpha-Glucosidase › New diarylheptanoid dimers as GLP-1...