DDR1 associates with TRPV4 in cell-matrix adhesions to enable calcium-regulated myosin activity and collagen compaction.
calcium
cell adhesion
collagen remodeling
extracellular matrix
myosin
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
10
01
2022
received:
24
06
2021
accepted:
27
01
2022
pubmed:
13
2
2022
medline:
27
5
2022
entrez:
12
2
2022
Statut:
ppublish
Résumé
Tissue fibrosis manifests as excessive deposition of compacted, highly aligned collagen fibrils, which interfere with organ structure and function. Cells in collagen-rich lesions often exhibit marked overexpression of discoidin domain receptor 1 (DDR1), which is linked to increased collagen compaction through the association of DDR1 with the Ca
Substances chimiques
Calcium, Dietary
0
TRPV Cation Channels
0
Collagen
9007-34-5
Discoidin Domain Receptor 1
EC 2.7.10.1
Myosins
EC 3.6.4.1
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2451-2468Subventions
Organisme : Canadian Institutes for Health Research
ID : MOP-503020
Informations de copyright
© 2022 Wiley Periodicals LLC.
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