Chronic Systemic Dexamethasone Regulates the Mineralocorticoid/Glucocorticoid Pathways Balance in Rat Ocular Tissues.
Animals
Central Serous Chorioretinopathy
/ drug therapy
Choroid
/ drug effects
Corticosterone
/ blood
Dexamethasone
/ metabolism
Eye
/ metabolism
Glucocorticoids
/ metabolism
Hypothalamo-Hypophyseal System
/ metabolism
Mineralocorticoids
/ metabolism
Ocular Physiological Phenomena
/ drug effects
Pituitary-Adrenal System
/ metabolism
Rats
Rats, Inbred Lew
Receptors, Glucocorticoid
/ metabolism
Retina
/ drug effects
Retinal Pigment Epithelium
/ drug effects
Signal Transduction
/ genetics
central serous chorioretinopathy
glucocorticoid
mineralocorticoid
retina
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Jan 2022
24 Jan 2022
Historique:
received:
01
12
2021
revised:
20
01
2022
accepted:
20
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
8
3
2022
Statut:
epublish
Résumé
Central serous chorioretinopathy (CSCR) is a retinal disease affecting the retinal pigment epithelium (RPE) and the choroid. This is a recognized side-effect of glucocorticoids (GCs), administered through nasal, articular, oral and dermal routes. However, CSCR does not occur after intraocular GCs administration, suggesting that a hypothalamic-pituitary-adrenal axis (HPA) brake could play a role in the mechanistic link between CSCR and GS. The aim of this study was to explore this hypothesis. To induce HPA brake, Lewis rats received a systemic injection of dexamethasone daily for five days. Control rats received saline injections. Baseline levels of corticosterone were measured by Elisa at baseline and at 5 days in the serum and the ocular media and dexamethasone levels were measured at 5 days in the serum and ocular media. The expression of genes encoding glucocorticoid receptor (GR), mineralocorticoid receptors (MR), and the 11 beta hydroxysteroid dehydrogenase (HSD) enzymes 1 and 2 were quantified in the neural retina and in RPE/ choroid. The expression of MR target genes was quantified in the retina (
Identifiants
pubmed: 35163201
pii: ijms23031278
doi: 10.3390/ijms23031278
pmc: PMC8836134
pii:
doi:
Substances chimiques
Glucocorticoids
0
Mineralocorticoids
0
Receptors, Glucocorticoid
0
Dexamethasone
7S5I7G3JQL
Corticosterone
W980KJ009P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : UNADEV
ID : MR-A-MD
Organisme : Agence Nationale de la Recherche
ID : 2020-20-CE17-0034
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