Genetics of Pheochromocytomas and Paragangliomas Determine the Therapeutical Approach.
germline
hereditary tumor
metastatic
paraganglioma
personalized medicine
pheochromocytoma
somatic
susceptibility genes
treatment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Jan 2022
27 Jan 2022
Historique:
received:
17
12
2021
revised:
21
01
2022
accepted:
24
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
9
3
2022
Statut:
epublish
Résumé
Pheochromocytomas and paragangliomas are the most heritable endocrine tumors. In addition to the inherited mutation other driver mutations have also been identified in tumor tissues. All these genetic alterations are clustered in distinct groups which determine the pathomechanisms. Most of these tumors are benign and their surgical removal will resolve patient management. However, 5-15% of them are malignant and therapeutical possibilities for them are limited. This review provides a brief insight about the tumorigenesis associated with pheochromocytomas/paragangliomas in order to present them as potential therapeutical targets.
Identifiants
pubmed: 35163370
pii: ijms23031450
doi: 10.3390/ijms23031450
pmc: PMC8836037
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Laboratories Excellence Program
ID : National Tumorbiology Laboratory project (NLP-17)
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