Exposure to b-LED Light While Exerting Antimicrobial Activity on Gram-Negative and -Positive Bacteria Promotes Transient EMT-like Changes and Growth Arrest in Keratinocytes.
Antigens, CD
/ metabolism
Cadherins
/ metabolism
Cell Cycle Checkpoints
/ radiation effects
Cell Proliferation
Cyclin D1
/ metabolism
Cyclin-Dependent Kinase Inhibitor p21
/ metabolism
Down Syndrome
Epithelial-Mesenchymal Transition
/ radiation effects
Gene Expression Regulation
/ drug effects
HaCaT Cells
Humans
Keratinocytes
/ cytology
Light
/ adverse effects
Microbial Viability
/ radiation effects
Pseudomonas aeruginosa
/ growth & development
Snail Family Transcription Factors
/ metabolism
Staphylococcus aureus
/ growth & development
EMT
b-led light
genotoxic damage
skin infections
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Feb 2022
08 Feb 2022
Historique:
received:
18
01
2022
revised:
01
02
2022
accepted:
02
02
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
5
3
2022
Statut:
epublish
Résumé
While blue LED (b-LED) light is increasingly being studied for its cytotoxic activity towards bacteria in therapy of skin-related infections, its effects on eukaryotic cells plasticity are less well characterized. Moreover, since different protocols are often used, comparing the effect of b-LED towards both microorganisms and epithelial surfaces may be difficult. The aim of this study was to analyze, in the same experimental setting, both the bactericidal activity and the effects on human keratinocytes. Exposure to b-LED induced an intense cytocidal activity against Gram-positive (i.e,
Identifiants
pubmed: 35163819
pii: ijms23031896
doi: 10.3390/ijms23031896
pmc: PMC8837184
pii:
doi:
Substances chimiques
Antigens, CD
0
CCND1 protein, human
0
CDH1 protein, human
0
CDKN1A protein, human
0
Cadherins
0
Cyclin-Dependent Kinase Inhibitor p21
0
SNAI1 protein, human
0
Snail Family Transcription Factors
0
Cyclin D1
136601-57-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Sapienza University of Rome
ID : RM11916B6A28725C
Organisme : Italian Ministry for Education, University and Research
ID : FISR 2020-Covid FISR2020IP_03366
Organisme : Italian Ministry for Health
ID : Ricerca Corrente
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