Epistatic genetic interactions govern morphogenesis during sexual reproduction and infection in a global human fungal pathogen.

Biological Evolution Cryptococcosis / genetics Cryptococcus / genetics Epistasis, Genetic / genetics Fungal Proteins / genetics Genes, Mating Type, Fungal / genetics Hyphae / growth & development Morphogenesis Phenotype Quantitative Trait Loci / genetics Reproduction / genetics Reproduction, Asexual
Cryptococcus QTL cell development genetic variation pathogenicity

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
22 02 2022
Historique:
accepted: 11 01 2022
entrez: 16 2 2022
pubmed: 17 2 2022
medline: 15 3 2022
Statut: ppublish

Résumé

Cellular development is orchestrated by evolutionarily conserved signaling pathways, which are often pleiotropic and involve intra- and interpathway epistatic interactions that form intricate, complex regulatory networks.

Identifiants

DOI: 10.1073/pnas.2122293119 PMID: 35169080 PMC: PMC8872808
pubmed: 35169080
pii: 2122293119
doi: 10.1073/pnas.2122293119
pmc: PMC8872808
pii:
doi:

Substances chimiques

Fungal Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI039115
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI050113
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI133654
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI039115
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2022 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no competing interest.

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Auteurs

Sheng Sun (S)

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
ORCID: 0000-0002-2895-1153

Cullen Roth (C)

Department of Biology, Duke University, Durham, NC 27708.

Anna Floyd Averette (A)

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
ORCID: 0000-0002-5877-0812

Paul M Magwene (PM)

Department of Biology, Duke University, Durham, NC 27708.
ORCID: 0000-0002-7659-2589

Joseph Heitman (J)

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710; heitm001@duke.edu.
ORCID: 0000-0001-6369-5995

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Classifications MeSH

questionsmedicales.fr › Phénomènes biologiques › Évolution biologique › Epistatic genetic interactions govern...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Mycoses › Cryptococcose › Epistatic genetic interactions govern...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Cryptococcus › Epistatic genetic interactions govern...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épistasie › Epistatic genetic interactions govern...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Epistatic genetic interactions govern...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome fongique › Gènes fongiques › Gènes fongiques du type conjugant › Epistatic genetic interactions govern...
questionsmedicales.fr › Structures fongiques › Mycelium › Hyphae › Epistatic genetic interactions govern...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Epistatic genetic interactions govern...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Epistatic genetic interactions govern...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Epistatic genetic interactions govern...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Epistatic genetic interactions govern...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Reproduction asexuée › Epistatic genetic interactions govern...