Brush-Like Interface on Surface-Attached Hydrogels Repels Proteins and Bacteria.
antiadhesive coating
antifouling
brush-like structure
nanoindentation
ultrathin hydrogel
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
07
02
2022
received:
17
01
2022
pubmed:
17
2
2022
medline:
18
5
2022
entrez:
16
2
2022
Statut:
ppublish
Résumé
Interfacing artificial materials with biological tissues remains a challenge. The direct contact of their surface with the biological milieu results in multiscale interactions, in which biomacromolecules adsorb and act as transducers mediating the interactions with cells and tissues. So far, only antifouling polymer brushes have been able to conceal the surface of synthetic materials. However, their complex synthesis has precluded their translation to applications. Here, it is shown that ultrathin surface-attached hydrogel coatings of N-(2-hydroxypropyl) methacrylamide (HPMA) and carboxybetaine methacrylamide (CBMAA) provide the same level of protection as brushes. In spite of being readily applicable, these coatings prevent the fouling from whole blood plasma and provide a barrier to the adhesion of Gram positive and negative bacteria. The analysis of the components of the surface free energy and nanoindentation experiments reveals that the excellent antifouling properties stem from the strong surface hydrophilicity and the presence of a brush-like structure at the water interface. Moreover, these coatings can be functionalized to achieve antimicrobial activity while remaining stealth and non-cytotoxic to eukaryotic cells. Such level of performance is previously only achieved with brushes. Thus, it is anticipated that this readily applicable strategy is a promising route to enhance the biocompatibility of real biomedical devices.
Identifiants
pubmed: 35170202
doi: 10.1002/mabi.202200025
doi:
Substances chimiques
Coated Materials, Biocompatible
0
Hydrogels
0
Polymers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200025Informations de copyright
© 2022 The Authors. Macromolecular Bioscience published by Wiley-VCH GmbH.
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