Lamina-associated domains: Tethers and looseners.

Chromatin Gene Expression Regulation Genome Nuclear Lamina

Journal

Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428

Informations de publication

Date de publication:
02 2022
Historique:
received: 06 12 2021
revised: 10 01 2022
accepted: 15 01 2022
pubmed: 22 2 2022
medline: 4 5 2022
entrez: 21 2 2022
Statut: ppublish

Résumé

Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at the nuclear lamina (NL). A major question is how LAD-NL interactions are mediated and controlled. Here, we review recent progress in the search for molecular tethers and looseners of LADs and we discuss the link between LAD-NL tethering, transcription regulation, and genome replication. We also provide a brief summary of technological advances that may uncover new aspects of LAD biology.

Identifiants

DOI: 10.1016/j.ceb.2022.01.004 PMID: 35189475
pubmed: 35189475
pii: S0955-0674(22)00005-9
doi: 10.1016/j.ceb.2022.01.004
pii:
doi:

Substances chimiques

Chromatin 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

80-87

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest statement Nothing declared.

Auteurs

Stefano Giustino Manzo (SG)

Division of Gene Regulation and Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands.

Lise Dauban (L)

Division of Gene Regulation and Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands.

Bas van Steensel (B)

Division of Gene Regulation and Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands; Department of Cell Biology, Erasmus University Medical Center, Rotterdam. Electronic address: b.v.steensel@nki.nl.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Lamina-associated domains: Tethers and looseners.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Lamina-associated domains: Tethers and looseners.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Lamina-associated domains: Tethers and looseners.
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Membranes intracellulaires › Enveloppe nucléaire › Lamina nucléaire › Lamina-associated domains: Tethers and looseners.