Inhibiting uptake activity of organic anion transporter 2 by bile acids.

Bile Acids and Salts / pharmacology Biological Transport Liver / metabolism Membrane Transport Proteins / metabolism Organic Anion Transporters / metabolism
Bile acid Cholestasis MDCK-hOAT2 SLC22A7 SNP

Journal

Drug metabolism and pharmacokinetics
ISSN: 1880-0920
Titre abrégé: Drug Metab Pharmacokinet
Pays: England
ID NLM: 101164773

Informations de publication

Date de publication:
Apr 2022
Historique:
received: 16 07 2021
revised: 17 12 2021
accepted: 18 01 2022
pubmed: 23 2 2022
medline: 17 3 2022
entrez: 22 2 2022
Statut: ppublish

Résumé

Bile acids, a series of amphiphilic molecules, can interact with several drug transporters and impact drug ADME. Organic anion transporter 2 (OAT2) is exclusively expressed in the liver and kidney. However, the interaction between bile acids and hOAT2 is unelucidated. In this study, we observed that chenodeoxycholic acid, deoxycholic acid, ursodeoxycholic acid, glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid, glycoursodeoxycholic acid (GUDCA), taurocholic acid (TCA), taurochenodeoxycholic acid (TCDCA), taurodeoxycholic acid, tauroursodeoxycholic acid could all inhibit uptake activity of hOAT2 while glycocholic acid (GCA) and cholic acid could not. Among them, TCDCA was the strongest inhibitor with IC

Identifiants

DOI: 10.1016/j.dmpk.2022.100448 PMID: 35190308
pubmed: 35190308
pii: S1347-4367(22)00005-2
doi: 10.1016/j.dmpk.2022.100448
pii:
doi:

Substances chimiques

Bile Acids and Salts 0
Membrane Transport Proteins 0
Organic Anion Transporters 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

100448

Informations de copyright

Copyright © 2022 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.

Auteurs

Yu Wang (Y)

Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Cancer Center of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310006, China.

Haihong Hu (H)

Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Cancer Center of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310006, China.

Jing Nie (J)

Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Cancer Center of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310006, China.

Hui Zhou (H)

Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Cancer Center of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310006, China.

Lushan Yu (L)

Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Cancer Center of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310006, China.

Su Zeng (S)

Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Cancer Center of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310006, China. Electronic address: zengsu@zju.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Acides et sels biliaires › Inhibiting uptake activity of organic anion...
questionsmedicales.fr › Métabolisme › Transport biologique › Inhibiting uptake activity of organic anion...
questionsmedicales.fr › Système digestif › Foie › Inhibiting uptake activity of organic anion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Inhibiting uptake activity of organic anion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Inhibiting uptake activity of organic anion...