High Mobility Group A1 Regulates Transcription Levels of Oligodendrocyte Marker Genes in Cultured Oligodendrocyte Precursor Cells.
HMGA1
cell differentiation
epigenetic regulator
oligodendrocyte precursor cell
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Feb 2022
17 Feb 2022
Historique:
received:
28
12
2021
revised:
02
02
2022
accepted:
03
02
2022
entrez:
26
2
2022
pubmed:
27
2
2022
medline:
24
3
2022
Statut:
epublish
Résumé
Oligodendrocyte precursor cells (OPCs) serve as progenitor cells of terminally differentiated oligodendrocytes. Past studies have confirmed the importance of epigenetic system in OPC differentiation to oligodendrocytes. High mobility group A1 (HMGA1) is a small non-histone nuclear protein that binds DNA and modifies the chromatin conformational state. However, it is still completely unknown about the roles of HMGA1 in the process of OPC differentiation. In this study, we prepared primary OPC cultures from the neonatal rat cortex and examined whether the loss- and gain-of-function of HMGA1 would change the mRNA levels of oligodendrocyte markers, such as
Identifiants
pubmed: 35216347
pii: ijms23042236
doi: 10.3390/ijms23042236
pmc: PMC8878090
pii:
doi:
Substances chimiques
Genetic Markers
0
Hmga1 protein, rat
0
RNA, Messenger
0
RNA, Small Interfering
0
HMGA1a Protein
124544-67-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Institute of Health
ID : R01NS113556
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